Cancer stem cells in solid tumors

Hajime Hirose; Hirofumi Yamamoto; Norikatsu Miyoshi; Mamoru Uemura; Susumu Miyazaki; Hidekazu Takahashi; Ichiro Takemasa; Tsunekazu Mizushima; Masataka Ikeda; Hideshi Ishii; Mitsugu Sekimoto; Yuichiro Doki; Masaki Mori

Cancer stem cells in solid tumors

Hajime Hirose, Hirofumi Yamamoto, Norikatsu Miyoshi, Mamoru Uemura, Susumu Miyazaki, Hidekazu Takahashi, Ichiro Takemasa, Tsunekazu Mizushima, Masataka Ikeda, Hideshi Ishii, Mitsugu Sekimoto, Yuichiro Doki, Masaki Mori

Research output: Contribution to journal › Review article › peer-review

6 Citations (Scopus)

Abstract

In this review, we discuss recent issues about cancer stem cells, especially in solid tumors. Cancer stem cells show the ability to self-renew; and they possess multi-potential differentiation and tumorigenic potential. Cancer stem cells are reported to show resistance to anticancer drugs and radiotherapy, and therefore, they are involved in progression, recurrence, and metastasis in cancer. The existence of cancer stem cells in leukemia has long been known, since early times. In recent years cancer stem cells have been identified in solid tumors of breast, prostate, lung, brain, colon, and pancreas, owing to the development of identification techniques using cell surface markers. Although many features remain to be addressed, it is expected that cancer stem cells could be a main target for cancer therapy in the near future.

Original language	English
Pages (from-to)	2809-2812
Number of pages	4
Journal	Japanese Journal of Cancer and Chemotherapy
Volume	37
Issue number	13
Publication status	Published - Dec 2010
Externally published	Yes

All Science Journal Classification (ASJC) codes

Medicine(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Cancer stem cells in solid tumors",

abstract = "In this review, we discuss recent issues about cancer stem cells, especially in solid tumors. Cancer stem cells show the ability to self-renew; and they possess multi-potential differentiation and tumorigenic potential. Cancer stem cells are reported to show resistance to anticancer drugs and radiotherapy, and therefore, they are involved in progression, recurrence, and metastasis in cancer. The existence of cancer stem cells in leukemia has long been known, since early times. In recent years cancer stem cells have been identified in solid tumors of breast, prostate, lung, brain, colon, and pancreas, owing to the development of identification techniques using cell surface markers. Although many features remain to be addressed, it is expected that cancer stem cells could be a main target for cancer therapy in the near future.",

author = "Hajime Hirose and Hirofumi Yamamoto and Norikatsu Miyoshi and Mamoru Uemura and Susumu Miyazaki and Hidekazu Takahashi and Ichiro Takemasa and Tsunekazu Mizushima and Masataka Ikeda and Hideshi Ishii and Mitsugu Sekimoto and Yuichiro Doki and Masaki Mori",

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TY - JOUR

T1 - Cancer stem cells in solid tumors

AU - Hirose, Hajime

AU - Yamamoto, Hirofumi

AU - Miyoshi, Norikatsu

AU - Uemura, Mamoru

AU - Miyazaki, Susumu

AU - Takahashi, Hidekazu

AU - Takemasa, Ichiro

AU - Mizushima, Tsunekazu

AU - Ikeda, Masataka

AU - Ishii, Hideshi

AU - Sekimoto, Mitsugu

AU - Doki, Yuichiro

AU - Mori, Masaki

PY - 2010/12

Y1 - 2010/12

N2 - In this review, we discuss recent issues about cancer stem cells, especially in solid tumors. Cancer stem cells show the ability to self-renew; and they possess multi-potential differentiation and tumorigenic potential. Cancer stem cells are reported to show resistance to anticancer drugs and radiotherapy, and therefore, they are involved in progression, recurrence, and metastasis in cancer. The existence of cancer stem cells in leukemia has long been known, since early times. In recent years cancer stem cells have been identified in solid tumors of breast, prostate, lung, brain, colon, and pancreas, owing to the development of identification techniques using cell surface markers. Although many features remain to be addressed, it is expected that cancer stem cells could be a main target for cancer therapy in the near future.

AB - In this review, we discuss recent issues about cancer stem cells, especially in solid tumors. Cancer stem cells show the ability to self-renew; and they possess multi-potential differentiation and tumorigenic potential. Cancer stem cells are reported to show resistance to anticancer drugs and radiotherapy, and therefore, they are involved in progression, recurrence, and metastasis in cancer. The existence of cancer stem cells in leukemia has long been known, since early times. In recent years cancer stem cells have been identified in solid tumors of breast, prostate, lung, brain, colon, and pancreas, owing to the development of identification techniques using cell surface markers. Although many features remain to be addressed, it is expected that cancer stem cells could be a main target for cancer therapy in the near future.

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M3 - Review article

C2 - 21160254

AN - SCOPUS:79960940557

SN - 0385-0684

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JO - Japanese Journal of Cancer and Chemotherapy

JF - Japanese Journal of Cancer and Chemotherapy

IS - 13

ER -

Cancer stem cells in solid tumors

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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