Cancer stem cells depend on their own niche

Yoshihiro Kano, Hideshi Ishii, Masamitsu Konno, Katsuya Ohta, Shimpei Nishikawa, Takahito Fukusumi, Atsushi Hamabe, Shinichiro Hasegawa, Hisataka Ogawa, Miyuki Ozaki, Yuko Noguchi, Daisuke Sakai, Naotsugu Haraguchi, Toshihiro Kudo, Taroh Satoh, Yuichiro Doki, Masaki Mori

Research output: Contribution to journalReview articlepeer-review


It is considered that cancer stem cells have the same characteristics as normal stem cells, such as drug-resistance, self--renewal, differentiation, and tissue-formation. Normal stem cells depend on their surroundings, a niche. Cancer stem cells may also depend on their own niche. Because cancer stem cells are resistant to present remedies, it is important to find a remedy targeting cancer stem cells. The remedy must not only target cancer stem cells themselves but also target the niche surrounding the cancer stem cells.

Original languageEnglish
Pages (from-to)419-423
Number of pages5
JournalJapanese Journal of Cancer and Chemotherapy
Issue number4
Publication statusPublished - Apr 2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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