TY - JOUR
T1 - Cancer stem cell theory in gastrointestinal malignancies
T2 - recent progress and upcoming challenges.
AU - Dewi, Dyah Laksmi
AU - Ishii, Hideshi
AU - Kano, Yoshihiro
AU - Nishikawa, Shinpei
AU - Haraguchi, Naotsugu
AU - Sakai, Daisuke
AU - Satoh, Taroh
AU - Doki, Yuichiro
AU - Mori, Masaki
PY - 2011/10
Y1 - 2011/10
N2 - A growing body of evidence supports the notion that malignant tumors are heterogeneous and contain diverse subpopulations of cells with unique characteristics including the ability to initiate a tumor and metastasize. This phenomenon might be explained by the so-called cancer stem cell (CSC) theory. Recent technological developments have allowed a deeper understanding and characterization of CSCs. Even though the application of this theory to hematopoietic malignancies and solid tumors holds promise for new ways to treat cancer, it also brings some skepticism. Efficacious therapeutic approaches targeting the CSC population should be explored to overcome therapeutic failure and improve patient outcomes. This review will focus on the intrinsic and extrinsic regulation of CSCs, as well as the development of therapeutic approaches against CSCs, predominantly focusing on gastrointestinal malignancies.
AB - A growing body of evidence supports the notion that malignant tumors are heterogeneous and contain diverse subpopulations of cells with unique characteristics including the ability to initiate a tumor and metastasize. This phenomenon might be explained by the so-called cancer stem cell (CSC) theory. Recent technological developments have allowed a deeper understanding and characterization of CSCs. Even though the application of this theory to hematopoietic malignancies and solid tumors holds promise for new ways to treat cancer, it also brings some skepticism. Efficacious therapeutic approaches targeting the CSC population should be explored to overcome therapeutic failure and improve patient outcomes. This review will focus on the intrinsic and extrinsic regulation of CSCs, as well as the development of therapeutic approaches against CSCs, predominantly focusing on gastrointestinal malignancies.
UR - http://www.scopus.com/inward/record.url?scp=85027951141&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85027951141&partnerID=8YFLogxK
U2 - 10.1007/s00535-011-0442-6
DO - 10.1007/s00535-011-0442-6
M3 - Review article
C2 - 21858638
AN - SCOPUS:85027951141
SN - 0944-1174
VL - 46
SP - 1145
EP - 1157
JO - Journal of gastroenterology
JF - Journal of gastroenterology
IS - 10
ER -
