Cancer of unknown primary site - Current status and future direction

Yasuko Ichikawa, Isamu Okamoto, Kazuhiko Nakagawa

Research output: Contribution to journalArticlepeer-review


Cancer of unknown primary site (CUP) is not a rare entity for 3-5% of all malignant neoplasms. CUP is diagnosed with metastatic lesion so they are all in the advanced stage. The diagnosis is made by biopsy. Patients with CUP need to have a physical examination, basic blood examination and appropriate diagnostic imaging. Those are valuable for final diagnosis of primary site determination. Systemic chemotherapy is applied in many cases, but the standard therapeutic strategy has not yet been determined.

Original languageEnglish
Pages (from-to)907-909
Number of pages3
JournalJapanese Journal of Cancer and Chemotherapy
Issue number6
Publication statusPublished - Jun 2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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