Campylobacter jejuni DNA-binding protein from starved cells in Guillain-Barré syndrome patients

Nobutoshi Kawamura; Hua Piao; Motozumi Minohara; Takuya Matsushita; Susumu Kusunoki; Hiroshi Matsumoto; Kazuhiro Ikenaka; Yoshimitsu Mizunoe; Jun ichi Kira

doi:10.1016/j.jneuroim.2011.09.004

Campylobacter jejuni DNA-binding protein from starved cells in Guillain-Barré syndrome patients

Nobutoshi Kawamura
, Hua Piao
, Motozumi Minohara
, Takuya Matsushita
, Susumu Kusunoki
, Hiroshi Matsumoto
, Kazuhiro Ikenaka
, Yoshimitsu Mizunoe
, Jun ichi Kira

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Campylobacter jejuni enteritis is frequently associated with an axonal form of Guillain-Barré syndrome (GBS) and C. jejuni DNA-binding protein from starved cells (C-Dps) induces paranodal myelin detachment and axonal degeneration through binding with sulfatide in vivo. Here we investigated the invasion of C-Dps into hosts with C. jejuni-related GBS. Our analyses of patient sera found that both C-Dps and anti-C-Dps antibodies were most commonly detected in sera from C. jejuni-related GBS patients (5/27, 14.8% and 15/24, 62.5%; respectively). These findings suggest that C-Dps invades the host and may potentially contribute to the peripheral nerve damage in C. jejuni-related GBS.

Original language	English
Pages (from-to)	74-78
Number of pages	5
Journal	Journal of Neuroimmunology
Volume	240-241
DOIs	https://doi.org/10.1016/j.jneuroim.2011.09.004
Publication status	Published - Dec 15 2011

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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10.1016/j.jneuroim.2011.09.004

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@article{f88c47ecc61a486ca95ea1f0fd1760aa,

title = "Campylobacter jejuni DNA-binding protein from starved cells in Guillain-Barr{\'e} syndrome patients",

abstract = "Campylobacter jejuni enteritis is frequently associated with an axonal form of Guillain-Barr{\'e} syndrome (GBS) and C. jejuni DNA-binding protein from starved cells (C-Dps) induces paranodal myelin detachment and axonal degeneration through binding with sulfatide in vivo. Here we investigated the invasion of C-Dps into hosts with C. jejuni-related GBS. Our analyses of patient sera found that both C-Dps and anti-C-Dps antibodies were most commonly detected in sera from C. jejuni-related GBS patients (5/27, 14.8\% and 15/24, 62.5\%; respectively). These findings suggest that C-Dps invades the host and may potentially contribute to the peripheral nerve damage in C. jejuni-related GBS.",

author = "Nobutoshi Kawamura and Hua Piao and Motozumi Minohara and Takuya Matsushita and Susumu Kusunoki and Hiroshi Matsumoto and Kazuhiro Ikenaka and Yoshimitsu Mizunoe and Kira, \{Jun ichi\}",

note = "Funding Information: This work was supported in part by grants from the Ministry of Education, Culture, Sports, Science and Technology of Japan , a Neuroimmunological Disease Research Committee grant from the Ministry of Health, Labour and Welfare of Japan and a grant for Research on Brain Science.",

year = "2011",

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doi = "10.1016/j.jneuroim.2011.09.004",

language = "English",

volume = "240-241",

pages = "74--78",

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T1 - Campylobacter jejuni DNA-binding protein from starved cells in Guillain-Barré syndrome patients

AU - Kawamura, Nobutoshi

AU - Piao, Hua

AU - Minohara, Motozumi

AU - Matsushita, Takuya

AU - Kusunoki, Susumu

AU - Matsumoto, Hiroshi

AU - Ikenaka, Kazuhiro

AU - Mizunoe, Yoshimitsu

AU - Kira, Jun ichi

N1 - Funding Information: This work was supported in part by grants from the Ministry of Education, Culture, Sports, Science and Technology of Japan , a Neuroimmunological Disease Research Committee grant from the Ministry of Health, Labour and Welfare of Japan and a grant for Research on Brain Science.

PY - 2011/12/15

Y1 - 2011/12/15

N2 - Campylobacter jejuni enteritis is frequently associated with an axonal form of Guillain-Barré syndrome (GBS) and C. jejuni DNA-binding protein from starved cells (C-Dps) induces paranodal myelin detachment and axonal degeneration through binding with sulfatide in vivo. Here we investigated the invasion of C-Dps into hosts with C. jejuni-related GBS. Our analyses of patient sera found that both C-Dps and anti-C-Dps antibodies were most commonly detected in sera from C. jejuni-related GBS patients (5/27, 14.8% and 15/24, 62.5%; respectively). These findings suggest that C-Dps invades the host and may potentially contribute to the peripheral nerve damage in C. jejuni-related GBS.

AB - Campylobacter jejuni enteritis is frequently associated with an axonal form of Guillain-Barré syndrome (GBS) and C. jejuni DNA-binding protein from starved cells (C-Dps) induces paranodal myelin detachment and axonal degeneration through binding with sulfatide in vivo. Here we investigated the invasion of C-Dps into hosts with C. jejuni-related GBS. Our analyses of patient sera found that both C-Dps and anti-C-Dps antibodies were most commonly detected in sera from C. jejuni-related GBS patients (5/27, 14.8% and 15/24, 62.5%; respectively). These findings suggest that C-Dps invades the host and may potentially contribute to the peripheral nerve damage in C. jejuni-related GBS.

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DO - 10.1016/j.jneuroim.2011.09.004

M3 - Article

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AN - SCOPUS:83555176383

SN - 0165-5728

VL - 240-241

SP - 74

EP - 78

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

ER -

Campylobacter jejuni DNA-binding protein from starved cells in Guillain-Barré syndrome patients

Abstract

All Science Journal Classification (ASJC) codes

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