TY - JOUR
T1 - Calcium, dairy foods, vitamin D, and colorectal cancer risk
T2 - The fukuoka colorectal cancer study
AU - Mizoue, Tetsuya
AU - Kimura, Yasumi
AU - Toyomura, Kengo
AU - Nagano, Jun
AU - Kono, Suminori
AU - Mibu, Ryuichi
AU - Tanaka, Masao
AU - Kakeji, Yoshihiro
AU - Maehara, Yoshihiko
AU - Okamura, Takeshi
AU - Ikejiri, Koji
AU - Futami, Kitaroh
AU - Yasunami, Yohichi
AU - Maekawa, Takafumi
AU - Takenaka, Kenji
AU - Ichimiya, Hitoshi
AU - Imaizumi, Nobutoshi
PY - 2008/10
Y1 - 2008/10
N2 - Epidemiologic evidence supporting a protective role of calcium and vitamin D in colorectal carcinogenesis has been accumulating in Western populations, but it is limited in Asian populations, whose intake of calcium is relatively low. We investigated the association of intakes of these nutrients with colorectal cancer risk in Japanese. Study subjects were participants of a large-scale case-control study in Fukuoka, Japan. Diet was assessed through interview regarding 148 dietary items by showing typical foods or dishes on the display of a personal computer. In a multivariate analysis adjusting for potential confounding variables, calcium intake was significantly, inversely associated with colorectal cancer risk (P for trend = 0.01); the odds ratio for the highest versus lowest quintile of calcium intake was 0.64 (95% confidence interval, 0.45-0.93). Higher levels of dietary vitamin D were significantly associated with decreased risk of colorectal cancer among those who had fewer chances of sunlight exposure at work or in leisure (P for trend = 0.02). A decreased risk of colorectal cancer associated with high calcium intake was observed among those who had higher levels of vitamin D intake or among those who had a greater chance of daily sunlight exposure, but not among those with medium or lower intake of vitamin D or among those with potentially decreased sunlight exposure. These results add to support for a joint action of calcium and vitamin D in the prevention of colorectal carcinogenesis.
AB - Epidemiologic evidence supporting a protective role of calcium and vitamin D in colorectal carcinogenesis has been accumulating in Western populations, but it is limited in Asian populations, whose intake of calcium is relatively low. We investigated the association of intakes of these nutrients with colorectal cancer risk in Japanese. Study subjects were participants of a large-scale case-control study in Fukuoka, Japan. Diet was assessed through interview regarding 148 dietary items by showing typical foods or dishes on the display of a personal computer. In a multivariate analysis adjusting for potential confounding variables, calcium intake was significantly, inversely associated with colorectal cancer risk (P for trend = 0.01); the odds ratio for the highest versus lowest quintile of calcium intake was 0.64 (95% confidence interval, 0.45-0.93). Higher levels of dietary vitamin D were significantly associated with decreased risk of colorectal cancer among those who had fewer chances of sunlight exposure at work or in leisure (P for trend = 0.02). A decreased risk of colorectal cancer associated with high calcium intake was observed among those who had higher levels of vitamin D intake or among those who had a greater chance of daily sunlight exposure, but not among those with medium or lower intake of vitamin D or among those with potentially decreased sunlight exposure. These results add to support for a joint action of calcium and vitamin D in the prevention of colorectal carcinogenesis.
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U2 - 10.1158/1055-9965.EPI-08-0369
DO - 10.1158/1055-9965.EPI-08-0369
M3 - Article
C2 - 18843026
AN - SCOPUS:54249087711
SN - 1055-9965
VL - 17
SP - 2800
EP - 2807
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
IS - 10
ER -
