Calcium-channel antagonists inhibit marble-burying behavior in mice

Nobuaki Egashira, Ryoko Okuno, Moe Abe, Michihiko Matsushita, Kenichi Mishima, Katsunori Iwasaki, Ryozo Oishi, Ryoji Nishimura, Yoshiaki Matsumoto, Michihiro Fujiwara

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


In the present study, we examined the effects of calcium-channel antagonists on marble-burying behavior, which is an animal model of obsessive-compulsive disorder. Amlodipine (10 mg/kg, i.p.), cilnidipine (10 mg/kg, i.p.), nilvadipine (3 and 10 mg/kg, i.p.), and flunarizine (30 mg/kg, i.p.) significantly inhibited marble-burying behavior in mice. These results suggest that calcium channels may be involved in the marble-burying behavior.

Original languageEnglish
Pages (from-to)140-143
Number of pages4
JournalJournal of Pharmacological Sciences
Issue number1
Publication statusPublished - 2008

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology


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