TY - JOUR
T1 - Calcium-channel antagonists inhibit marble-burying behavior in mice
AU - Egashira, Nobuaki
AU - Okuno, Ryoko
AU - Abe, Moe
AU - Matsushita, Michihiko
AU - Mishima, Kenichi
AU - Iwasaki, Katsunori
AU - Oishi, Ryozo
AU - Nishimura, Ryoji
AU - Matsumoto, Yoshiaki
AU - Fujiwara, Michihiro
N1 - Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2008
Y1 - 2008
N2 - In the present study, we examined the effects of calcium-channel antagonists on marble-burying behavior, which is an animal model of obsessive-compulsive disorder. Amlodipine (10 mg/kg, i.p.), cilnidipine (10 mg/kg, i.p.), nilvadipine (3 and 10 mg/kg, i.p.), and flunarizine (30 mg/kg, i.p.) significantly inhibited marble-burying behavior in mice. These results suggest that calcium channels may be involved in the marble-burying behavior.
AB - In the present study, we examined the effects of calcium-channel antagonists on marble-burying behavior, which is an animal model of obsessive-compulsive disorder. Amlodipine (10 mg/kg, i.p.), cilnidipine (10 mg/kg, i.p.), nilvadipine (3 and 10 mg/kg, i.p.), and flunarizine (30 mg/kg, i.p.) significantly inhibited marble-burying behavior in mice. These results suggest that calcium channels may be involved in the marble-burying behavior.
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U2 - 10.1254/jphs.08160SC
DO - 10.1254/jphs.08160SC
M3 - Article
C2 - 18758134
AN - SCOPUS:52949153524
SN - 1347-8613
VL - 108
SP - 140
EP - 143
JO - Journal of Pharmacological Sciences
JF - Journal of Pharmacological Sciences
IS - 1
ER -