Calcium-associated mechanisms in gut pacemaker activity: Interstitial Cajal-like Cells Review Series

Shinsuke Nakayama, Shunichi Kajioka, Kazunori Goto, Miyako Takaki, Hong Nian Liu

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)


Introduction Voltage-operated Ca2+ channels Non-selective cation channels Cl- channels [Ca2+]i oscillations Intracellular Ca2+ release channels ICC-like cells in auxiliary digestive organs A considerable body of evidence has revealed that interstitial cells of Cajal (ICC), identified with c-Kit-immunoreactivity, act as gut pacemaker cells, with spontaneous Ca2+ activity in ICC as the probable primary mechanism. Namely, intracellular (cytosolic) Ca2+ oscillations in ICC periodically activate plasmalemmal Ca2+-dependent ion channels and thereby generate pacemaker potentials. This review will, thus, focus on Ca2+-associated mechanisms in ICC in the gastrointestinal (GI) tract, including auxiliary organs.

Original languageEnglish
Pages (from-to)958-968
Number of pages11
JournalJournal of Cellular and Molecular Medicine
Issue number5
Publication statusPublished - Sept 2007
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Cell Biology


Dive into the research topics of 'Calcium-associated mechanisms in gut pacemaker activity: Interstitial Cajal-like Cells Review Series'. Together they form a unique fingerprint.

Cite this