CAD scheme for detection of intracranial aneurysms in MRA based on 3D analysis of vessel skeletons and enhanced aneurysms

Hidetaka Arimura, Qiang Li, Yukunori Korogi, Toshinori Hirai, Yasuyuki Yamashita, Shigehiko Katsuragawa, Ryuji Ikeda, Kunio Doi

Research output: Contribution to journalConference articlepeer-review

2 Citations (Scopus)


We have developed a computer-aided diagnostic (CAD) scheme for detection of unruptured intracranial aneurysms in magnetic resonance angiography (MRA) based on findings of short branches in vessel skeletons, and a three-dimensional (3D) selective enhancement filter for dots (aneurysms). Fifty-three cases with 61 unruptured aneurysms and 62 non-aneurysm cases were tested in this study. The Isotropic 3D MRA images with 400 × 400 × 128 voxels (a voxel size of 0.5 mm) were processed by use of the dot enhancement filter. The initial candidates were identified not only on the dot-enhanced images by use of a multiple gray-level thresholding technique, but also on the vessel skeletons by finding short branches on parent skeletons, which can indicate a high likelihood of small aneurysms. All candidates were classified into four categories of candidates according to effective diameter and local structure of the vessel skeleton. In each category, a number of false positives were removed by use of two rule-based schemes and by linear discriminant analysis on localized image features related to gray level and morphology. Our CAD scheme achieved a sensitivity of 97% with 5.0 false positives per patient by use of a leave-one-out-by-patient test method. This CAD system may be useful in assisting radiologists in the detection of small intracranial aneurysms as well as medium-size aneurysms in MRA.

Original languageEnglish
Article number102
Pages (from-to)967-974
Number of pages8
JournalProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Issue numberII
Publication statusPublished - 2005
EventMedical Imaging 2005 - Image Processing - San Diego, CA, United States
Duration: Feb 13 2005Feb 17 2005

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging


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