TY - JOUR
T1 - C-type lectin receptors in anti-fungal immunity
AU - Shiokawa, Moe
AU - Yamasaki, Sho
AU - Saijo, Shinobu
N1 - Funding Information:
This work was supported by a Grant-in-Aid for Scientific Research ( 26293099 ), a Grant-in-Aid for Scientific Research on Innovative Areas ( 26110009 ), a Grant-in Aid for Challenging Exploratory Research ( 16K15271 ) from MEXT and grants from the Ministry of Health, Labour, and Welfare ( MHLW ), Research on Development of New Drugs, and AMED-CREST , AMED , and Takeda Science Foundation . The authors appreciate Dr. Shigeru Kakuta for critical reading of this manuscript.
Publisher Copyright:
© 2017 Elsevier Ltd
PY - 2017/12
Y1 - 2017/12
N2 - Host immune systems are constantly engaged with fungal pathogens which are common in environments as well as in healthy human skin and mucosa. C-type lectin receptors (CLRs) are expressed in myeloid cells and play central roles in host defenses against fungal infections by coordinating innate and adaptive immune systems. Upon ligand binding, CLRs stimulate cellular responses by inducing the production of cytokines and reactive oxygen species via the Syk/CARD9 signaling pathway, leading to fungal elimination. Due to identification and characterization of the CLRs, the underlying mechanisms of the anti-fungal immunity are being unveiled in the present decade. In this review, we focus on the anti-fungal activities of CLRs and summarize of current knowledge of the related expression profiles, modes of ligand recognition, and signaling cascades.
AB - Host immune systems are constantly engaged with fungal pathogens which are common in environments as well as in healthy human skin and mucosa. C-type lectin receptors (CLRs) are expressed in myeloid cells and play central roles in host defenses against fungal infections by coordinating innate and adaptive immune systems. Upon ligand binding, CLRs stimulate cellular responses by inducing the production of cytokines and reactive oxygen species via the Syk/CARD9 signaling pathway, leading to fungal elimination. Due to identification and characterization of the CLRs, the underlying mechanisms of the anti-fungal immunity are being unveiled in the present decade. In this review, we focus on the anti-fungal activities of CLRs and summarize of current knowledge of the related expression profiles, modes of ligand recognition, and signaling cascades.
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U2 - 10.1016/j.mib.2017.11.004
DO - 10.1016/j.mib.2017.11.004
M3 - Review article
AN - SCOPUS:85034436145
SN - 1369-5274
VL - 40
SP - 123
EP - 130
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
ER -
