C-reactive protein: albumin ratio in patients with resectable intrahepatic cholangiocarcinoma

T. Matsumoto; S. Itoh; T. Yoshizumi; T. Kurihara; S. Yoshiya; Y. Mano; kazuki takeishi; Noboru Harada; T. Ikegami; Y. Soejima; H. Baba; M. Mori

doi:10.1002/bjs5.50348

C-reactive protein: albumin ratio in patients with resectable intrahepatic cholangiocarcinoma

T. Matsumoto, S. Itoh, T. Yoshizumi, T. Kurihara, S. Yoshiya, Y. Mano, kazuki takeishi, Noboru Harada, T. Ikegami, Y. Soejima, H. Baba, M. Mori

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Abstract

Background: The C-reactive protein : albumin ratio (CAR) has been reported as a novel prognostic marker in several cancers. The aim of this study was to investigate the prognostic value of CAR in patients with intrahepatic cholangiocarcinoma (ICC). Methods: This was a single-centre retrospective study of patients who underwent surgery for ICC in a university hospital in Japan between 1998 and 2018. CAR, Glasgow Prognostic Score (GPS) and modified GPS (mGPS) were calculated. Their correlation with recurrence-free survival (RFS) and overall survival (OS) was analysed with Cox proportional hazards models. Results: Seventy-two patients were included in the study. Patients were divided into two groups according to the optimal CAR cut-off value of 0·02. CAR above 0·02 was associated with higher carbohydrate antigen 19-9 levels (20·5 versus 66·1 units/ml for CAR of 0·02 or less; P = 0·002), larger tumour size (3·2 versus 4·4 cm respectively; P = 0·031) and a higher rate of microvascular invasion (9 of 28 versus 25 of 44; P = 0·041). RFS and OS were shorter in patients with CAR above 0·02: hazard ratio (HR) 4·31 (95 per cent c.i. 2·02 to 10·63) and HR 4·80 (1·85 to 16·40) respectively. In multivariable analysis CAR above 0·02 was an independent prognostic factor of RFS (HR 3·29 (1·33 to 8·12); P < 0·001), but not OS. Conclusions: CAR was associated with prognosis in patients who had hepatic resection for ICC.

Original language	English
Pages (from-to)	1146-1152
Number of pages	7
Journal	BJS open
Volume	4
Issue number	6
DOIs	https://doi.org/10.1002/bjs5.50348
Publication status	Published - Dec 2020

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Surgery

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/bjs5.50348

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@article{53cc4531ee4946d1a886f885572b6a4b,

title = "C-reactive protein: albumin ratio in patients with resectable intrahepatic cholangiocarcinoma",

abstract = "Background: The C-reactive protein : albumin ratio (CAR) has been reported as a novel prognostic marker in several cancers. The aim of this study was to investigate the prognostic value of CAR in patients with intrahepatic cholangiocarcinoma (ICC). Methods: This was a single-centre retrospective study of patients who underwent surgery for ICC in a university hospital in Japan between 1998 and 2018. CAR, Glasgow Prognostic Score (GPS) and modified GPS (mGPS) were calculated. Their correlation with recurrence-free survival (RFS) and overall survival (OS) was analysed with Cox proportional hazards models. Results: Seventy-two patients were included in the study. Patients were divided into two groups according to the optimal CAR cut-off value of 0·02. CAR above 0·02 was associated with higher carbohydrate antigen 19-9 levels (20·5 versus 66·1 units/ml for CAR of 0·02 or less; P = 0·002), larger tumour size (3·2 versus 4·4 cm respectively; P = 0·031) and a higher rate of microvascular invasion (9 of 28 versus 25 of 44; P = 0·041). RFS and OS were shorter in patients with CAR above 0·02: hazard ratio (HR) 4·31 (95 per cent c.i. 2·02 to 10·63) and HR 4·80 (1·85 to 16·40) respectively. In multivariable analysis CAR above 0·02 was an independent prognostic factor of RFS (HR 3·29 (1·33 to 8·12); P < 0·001), but not OS. Conclusions: CAR was associated with prognosis in patients who had hepatic resection for ICC.",

author = "T. Matsumoto and S. Itoh and T. Yoshizumi and T. Kurihara and S. Yoshiya and Y. Mano and kazuki takeishi and Noboru Harada and T. Ikegami and Y. Soejima and H. Baba and M. Mori",

note = "Funding Information: information Japan Society for the Promotion of Science, JP-16K10576, 19K09198The authors thank A. Morben from the Edanz Group (www.edanzediting.com/ac) for editing a draft of this manuscript. The study was supported by the Japan Society for the Promotion of Science, a Grant-in-Aid from the Ministry of Health, Labour and Welfare, Japan (numbers JP-16K10576 and 19K09198). The funding source had no role in the collection, analysis or interpretation of the data, or in the decision to submit the article for publication. Disclosure: The authors declare no conflict of interest. Publisher Copyright: {\textcopyright} 2020 The Authors. BJS Open published by John Wiley & Sons Ltd on behalf of British Journal of Surgery Society.",

year = "2020",

month = dec,

doi = "10.1002/bjs5.50348",

language = "English",

volume = "4",

pages = "1146--1152",

journal = "BJS open",

issn = "2474-9842",

publisher = "John Wiley & Sons Ltd.",

number = "6",

}

TY - JOUR

T1 - C-reactive protein

T2 - albumin ratio in patients with resectable intrahepatic cholangiocarcinoma

AU - Matsumoto, T.

AU - Itoh, S.

AU - Yoshizumi, T.

AU - Kurihara, T.

AU - Yoshiya, S.

AU - Mano, Y.

AU - takeishi, kazuki

AU - Harada, Noboru

AU - Ikegami, T.

AU - Soejima, Y.

AU - Baba, H.

AU - Mori, M.

N1 - Funding Information: information Japan Society for the Promotion of Science, JP-16K10576, 19K09198The authors thank A. Morben from the Edanz Group (www.edanzediting.com/ac) for editing a draft of this manuscript. The study was supported by the Japan Society for the Promotion of Science, a Grant-in-Aid from the Ministry of Health, Labour and Welfare, Japan (numbers JP-16K10576 and 19K09198). The funding source had no role in the collection, analysis or interpretation of the data, or in the decision to submit the article for publication. Disclosure: The authors declare no conflict of interest. Publisher Copyright: © 2020 The Authors. BJS Open published by John Wiley & Sons Ltd on behalf of British Journal of Surgery Society.

PY - 2020/12

Y1 - 2020/12

N2 - Background: The C-reactive protein : albumin ratio (CAR) has been reported as a novel prognostic marker in several cancers. The aim of this study was to investigate the prognostic value of CAR in patients with intrahepatic cholangiocarcinoma (ICC). Methods: This was a single-centre retrospective study of patients who underwent surgery for ICC in a university hospital in Japan between 1998 and 2018. CAR, Glasgow Prognostic Score (GPS) and modified GPS (mGPS) were calculated. Their correlation with recurrence-free survival (RFS) and overall survival (OS) was analysed with Cox proportional hazards models. Results: Seventy-two patients were included in the study. Patients were divided into two groups according to the optimal CAR cut-off value of 0·02. CAR above 0·02 was associated with higher carbohydrate antigen 19-9 levels (20·5 versus 66·1 units/ml for CAR of 0·02 or less; P = 0·002), larger tumour size (3·2 versus 4·4 cm respectively; P = 0·031) and a higher rate of microvascular invasion (9 of 28 versus 25 of 44; P = 0·041). RFS and OS were shorter in patients with CAR above 0·02: hazard ratio (HR) 4·31 (95 per cent c.i. 2·02 to 10·63) and HR 4·80 (1·85 to 16·40) respectively. In multivariable analysis CAR above 0·02 was an independent prognostic factor of RFS (HR 3·29 (1·33 to 8·12); P < 0·001), but not OS. Conclusions: CAR was associated with prognosis in patients who had hepatic resection for ICC.

AB - Background: The C-reactive protein : albumin ratio (CAR) has been reported as a novel prognostic marker in several cancers. The aim of this study was to investigate the prognostic value of CAR in patients with intrahepatic cholangiocarcinoma (ICC). Methods: This was a single-centre retrospective study of patients who underwent surgery for ICC in a university hospital in Japan between 1998 and 2018. CAR, Glasgow Prognostic Score (GPS) and modified GPS (mGPS) were calculated. Their correlation with recurrence-free survival (RFS) and overall survival (OS) was analysed with Cox proportional hazards models. Results: Seventy-two patients were included in the study. Patients were divided into two groups according to the optimal CAR cut-off value of 0·02. CAR above 0·02 was associated with higher carbohydrate antigen 19-9 levels (20·5 versus 66·1 units/ml for CAR of 0·02 or less; P = 0·002), larger tumour size (3·2 versus 4·4 cm respectively; P = 0·031) and a higher rate of microvascular invasion (9 of 28 versus 25 of 44; P = 0·041). RFS and OS were shorter in patients with CAR above 0·02: hazard ratio (HR) 4·31 (95 per cent c.i. 2·02 to 10·63) and HR 4·80 (1·85 to 16·40) respectively. In multivariable analysis CAR above 0·02 was an independent prognostic factor of RFS (HR 3·29 (1·33 to 8·12); P < 0·001), but not OS. Conclusions: CAR was associated with prognosis in patients who had hepatic resection for ICC.

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U2 - 10.1002/bjs5.50348

DO - 10.1002/bjs5.50348

M3 - Article

C2 - 32959537

AN - SCOPUS:85106254344

SN - 2474-9842

VL - 4

SP - 1146

EP - 1152

JO - BJS open

JF - BJS open

IS - 6

ER -

C-reactive protein: albumin ratio in patients with resectable intrahepatic cholangiocarcinoma

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