Broad Heterochromatic Domains Open in Gonocyte Development Prior to De Novo DNA Methylation

Soichiro Yamanaka; Hidenori Nishihara; Hidehiro Toh; Luis Augusto Eijy Nagai; Kosuke Hashimoto; Sung Joon Park; Aoi Shibuya; Ana Maria Suzuki; Yujiro Tanaka; Kenta Nakai; Piero Carninci; Hiroyuki Sasaki; Haruhiko Siomi

doi:10.1016/j.devcel.2019.07.023

Broad Heterochromatic Domains Open in Gonocyte Development Prior to De Novo DNA Methylation

Soichiro Yamanaka
, Hidenori Nishihara
, Hidehiro Toh
, Luis Augusto Eijy Nagai
, Kosuke Hashimoto
, Sung Joon Park
, Aoi Shibuya
, Ana Maria Suzuki
, Yujiro Tanaka
, Kenta Nakai
, Piero Carninci
, Hiroyuki Sasaki
, Haruhiko Siomi

Department of Molecular and Structural Biology

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Abstract

Genome-wide de novo DNA methylation occurs in mouse gonocytes, arrested male embryonic germ cells. However, how the methylome gets established in the genome of arrested cells remains unexplored. Yamanaka et al. report that multiple chromatin reprogramming pathways allow the access of methyltransferases to DNA in gonocytes.

Original language	English
Pages (from-to)	21-34.e5
Journal	Developmental Cell
Volume	51
Issue number	1
DOIs	https://doi.org/10.1016/j.devcel.2019.07.023
Publication status	Published - Oct 7 2019

All Science Journal Classification (ASJC) codes

Molecular Biology
General Biochemistry,Genetics and Molecular Biology
Developmental Biology
Cell Biology

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10.1016/j.devcel.2019.07.023

Cite this

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title = "Broad Heterochromatic Domains Open in Gonocyte Development Prior to De Novo DNA Methylation",

abstract = "Genome-wide de novo DNA methylation occurs in mouse gonocytes, arrested male embryonic germ cells. However, how the methylome gets established in the genome of arrested cells remains unexplored. Yamanaka et al. report that multiple chromatin reprogramming pathways allow the access of methyltransferases to DNA in gonocytes.",

keywords = "ATAC-seq, de novo DNA methylation, gene cluster, gene desert, gonocyte, transposon",

author = "Soichiro Yamanaka and Hidenori Nishihara and Hidehiro Toh and \{Eijy Nagai\}, \{Luis Augusto\} and Kosuke Hashimoto and Park, \{Sung Joon\} and Aoi Shibuya and Suzuki, \{Ana Maria\} and Yujiro Tanaka and Kenta Nakai and Piero Carninci and Hiroyuki Sasaki and Haruhiko Siomi",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

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doi = "10.1016/j.devcel.2019.07.023",

language = "English",

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T1 - Broad Heterochromatic Domains Open in Gonocyte Development Prior to De Novo DNA Methylation

AU - Yamanaka, Soichiro

AU - Nishihara, Hidenori

AU - Toh, Hidehiro

AU - Eijy Nagai, Luis Augusto

AU - Hashimoto, Kosuke

AU - Park, Sung Joon

AU - Shibuya, Aoi

AU - Suzuki, Ana Maria

AU - Tanaka, Yujiro

AU - Nakai, Kenta

AU - Carninci, Piero

AU - Sasaki, Hiroyuki

AU - Siomi, Haruhiko

PY - 2019/10/7

Y1 - 2019/10/7

N2 - Genome-wide de novo DNA methylation occurs in mouse gonocytes, arrested male embryonic germ cells. However, how the methylome gets established in the genome of arrested cells remains unexplored. Yamanaka et al. report that multiple chromatin reprogramming pathways allow the access of methyltransferases to DNA in gonocytes.

AB - Genome-wide de novo DNA methylation occurs in mouse gonocytes, arrested male embryonic germ cells. However, how the methylome gets established in the genome of arrested cells remains unexplored. Yamanaka et al. report that multiple chromatin reprogramming pathways allow the access of methyltransferases to DNA in gonocytes.

KW - ATAC-seq

KW - de novo DNA methylation

KW - gene cluster

KW - gene desert

KW - gonocyte

KW - transposon

UR - https://www.scopus.com/pages/publications/85072703324

UR - https://www.scopus.com/pages/publications/85072703324#tab=citedBy

U2 - 10.1016/j.devcel.2019.07.023

DO - 10.1016/j.devcel.2019.07.023

M3 - Article

C2 - 31474564

AN - SCOPUS:85072703324

SN - 1534-5807

VL - 51

SP - 21-34.e5

JO - Developmental Cell

JF - Developmental Cell

IS - 1

ER -

Broad Heterochromatic Domains Open in Gonocyte Development Prior to De Novo DNA Methylation

Abstract

All Science Journal Classification (ASJC) codes

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