TY - JOUR
T1 - Bright NIR-II fluorescence from biocompatible gel-coated carbon nanotubes for in vivo imaging
AU - Nagai, Yukiko
AU - Hamano, Ryo
AU - Nakamura, Kenta
AU - Widjaja, Isabella A.
AU - Tanaka, Naoki
AU - Zhang, Minfang
AU - Tanaka, Takeshi
AU - Kataura, Hiromichi
AU - Yudasaka, Masako
AU - Fujigaya, Tsuyohiko
N1 - Publisher Copyright:
© 2023 Elsevier Ltd
PY - 2024/1/31
Y1 - 2024/1/31
N2 - Near-infrared light in the second region (NIR-II, ∼1000–1400 nm) can penetrate biological tissues with minimal absorption and scattering, making it ideal for in vivo diagnostic imaging. However, most NIR-II-fluorescent materials lack adequate brightness and biocompatibility. One such example is single-walled carbon nanotube (SWCNT). In this study, we improved fluorescence brightness and biocompatibility of SWCNTs by coating them with gel of polyethylene glycol (PEG)-based cross-linked polymers, which was prepared by a one-pot method called “carbon nanotube micelle polymerization (CMP)”. The PEG confers SWCNT biocompatibility, and structural defects of SWCNT induced by CMP enhanced NIR-II fluorescence intensity. Due to these improvements, the gel-coated SWCNTs clearly imaged vasculatures in mice at a low dose of 8.4 μg/mouse, proving the potential use of gel-coated SWCNTs as high-quality bio-imaging agents.
AB - Near-infrared light in the second region (NIR-II, ∼1000–1400 nm) can penetrate biological tissues with minimal absorption and scattering, making it ideal for in vivo diagnostic imaging. However, most NIR-II-fluorescent materials lack adequate brightness and biocompatibility. One such example is single-walled carbon nanotube (SWCNT). In this study, we improved fluorescence brightness and biocompatibility of SWCNTs by coating them with gel of polyethylene glycol (PEG)-based cross-linked polymers, which was prepared by a one-pot method called “carbon nanotube micelle polymerization (CMP)”. The PEG confers SWCNT biocompatibility, and structural defects of SWCNT induced by CMP enhanced NIR-II fluorescence intensity. Due to these improvements, the gel-coated SWCNTs clearly imaged vasculatures in mice at a low dose of 8.4 μg/mouse, proving the potential use of gel-coated SWCNTs as high-quality bio-imaging agents.
UR - http://www.scopus.com/inward/record.url?scp=85180362016&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85180362016&partnerID=8YFLogxK
U2 - 10.1016/j.carbon.2023.118728
DO - 10.1016/j.carbon.2023.118728
M3 - Article
AN - SCOPUS:85180362016
SN - 0008-6223
VL - 218
JO - Carbon
JF - Carbon
M1 - 118728
ER -