TY - JOUR
T1 - Branches of the B cell antigen receptor pathway are directed by protein conduits Bam32 and Carma1
AU - Niiro, Hiroaki
AU - Clark, Edward A.
N1 - Funding Information:
Our work on this minireview was supported by National Institutes of Health grants AI45088 and AI44250.
PY - 2003/11
Y1 - 2003/11
N2 - Adaptor proteins act as conduits to channel upstream signals into downstream effector branches. Two B cell-associated adaptors, Bam32 and Carma1, regulate the ERK, JNK, and NF-κB branches of the BCR signaling pathway. Recent studies of Bam32-/- and Carma1-/- mice suggest that each adaptor controls a distinct conduit regulating either only proliferation (Bam32) or both the proliferation and survival of B cells (Carma1).
AB - Adaptor proteins act as conduits to channel upstream signals into downstream effector branches. Two B cell-associated adaptors, Bam32 and Carma1, regulate the ERK, JNK, and NF-κB branches of the BCR signaling pathway. Recent studies of Bam32-/- and Carma1-/- mice suggest that each adaptor controls a distinct conduit regulating either only proliferation (Bam32) or both the proliferation and survival of B cells (Carma1).
UR - http://www.scopus.com/inward/record.url?scp=0344927167&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0344927167&partnerID=8YFLogxK
U2 - 10.1016/S1074-7613(03)00303-0
DO - 10.1016/S1074-7613(03)00303-0
M3 - Review article
C2 - 14614850
AN - SCOPUS:0344927167
SN - 1074-7613
VL - 19
SP - 637
EP - 640
JO - Immunity
JF - Immunity
IS - 5
ER -
