Boronic Acid Accelerated Three-Component Reaction for the Synthesis of α-Sulfanyl-Substituted Indole-3-acetic Acids

Amrita Das, Kenji Watanabe, Hiroyuki Morimoto, Takashi Ohshima

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

Boronic acid was used to accelerate a three-component reaction of indoles, thiols, and glyoxylic acids for the synthesis of α-sulfanyl-substituted indole-3-acetic acids. Boronic acid catalysis to activate the α-hydroxy group in α-hydroxycarboxylic acid intermediates and intramolecular assistance by free carboxylic acid were the keys to accelerating the product formation.

Original languageEnglish
Pages (from-to)5794-5797
Number of pages4
JournalOrganic letters
Volume19
Issue number21
DOIs
Publication statusPublished - Nov 3 2017

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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