Bone regeneration by octacalcium phosphate and collagen composites

Shinji Kamakura, Takahisa Anada, Osamu Suzuki

Research output: Chapter in Book/Report/Conference proceedingChapter


Octacalcium phosphate (Ca8H2(PO4)6·5H2O; OCP) is a calcium phosphate and has been suggested to be a precursor of biological apatite crystals in bones and teeth. The importance of synthetic OCP as a bone substitute material was recently recognized in the field of tissue engineering for bone regeneration. Our previous studies elucidated the below-mentioned phenomena by using a rat calvarial defect model. OCP irreversibly converts to the apatitic phase, and the process of OCP-apatite conversion is involved in bone regeneration. Implanted OCP enhances bone regeneration more than hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP), which have already been used clinically as a scaffold for bone regeneration. OCP can be used as an effective scaffold for growth factors, such as bone morphogenetic protein-2 (BMP-2) and transforming growth factor-β1 (TGF-β1), to enhance bone regeneration. Although OCP possesses many desirable properties, OCP cannot be molded by a sintering process, unlike bioceramics, such as HA or β-TCP. To improve the performance of bone regeneration and handling performance, a composite synthetic bone substitute constructed of synthetic OCP and porcine atelocollagen sponge (OCP/Col) has been developed. The synergistic effects of OCP/Col on bone regeneration are the result of bone nucleation by OCP and cell infiltration by collagen, and OCP/Col shows stable bone regeneration. OCP/Col significantly enhances bone regeneration more than OCP per se, β-TCP collagen composite, and HA collagen composite if implanted into a critical-sized defect model in a rat calvarium. During optimization of OCP/Col, it was confirmed that bone regeneration by OCP/Col was influenced by dehydrothermal treatment in the fabrication of OCP/Col or the composition of OCP and collagen. As OCP/Col is applicable without cell transplantation and exogenous osteogenic cytokines, costeffective bone regenerative therapy is expected in the future.

Original languageEnglish
Title of host publicationBone Regeneration
Subtitle of host publicationGrowth Factors, Augmentation Procedures and Tissue Engineering Applications
PublisherNova Science Publishers, Inc.
Number of pages26
ISBN (Electronic)9781617618789
ISBN (Print)9781608766215
Publication statusPublished - Jan 1 2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Medicine


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