TY - GEN
T1 - Bone marrow cell response on carbonate apatite/PCL-coated α-tricalcium phosphate foam
AU - Le, Thi Bang
AU - Shi, Xing Ling
AU - Kunio, Ishikawa
AU - Othman, Radzali
PY - 2014
Y1 - 2014
N2 - The aim of this research work was to investigate in vitro effect of the carbonate apatite/poly(ε- caprolactone) (CO3Ap/PCL) on α-tricalcium phosphate (α-TCP) foam. α-TCP was produced by sintering CaCO3 and CaHPO4•2H2O at 1500°C for 5 h. It was then coated with CO3Ap/PCL (wt/wt=1/3) to improve both mechanical and biological properties. The initial cell attachment and proliferation of the bone marrow cells were carried out on the α-TCP and CO3Ap/PCL-coated α- TCP foams. The cell proliferation was calculated by AlamarBlue assay. The cells were able to migrate and proliferate well on both α-TCP and CO3Ap/PCL-coated α-TCP foams indicating an excellent biocompatibility. The incorporation of CO3Ap on the coating layer improved cellular attachment and accelerated proliferation. Thus, CO3Ap/PCL-coated α-TCP foam might be a promising candidate as implant material.
AB - The aim of this research work was to investigate in vitro effect of the carbonate apatite/poly(ε- caprolactone) (CO3Ap/PCL) on α-tricalcium phosphate (α-TCP) foam. α-TCP was produced by sintering CaCO3 and CaHPO4•2H2O at 1500°C for 5 h. It was then coated with CO3Ap/PCL (wt/wt=1/3) to improve both mechanical and biological properties. The initial cell attachment and proliferation of the bone marrow cells were carried out on the α-TCP and CO3Ap/PCL-coated α- TCP foams. The cell proliferation was calculated by AlamarBlue assay. The cells were able to migrate and proliferate well on both α-TCP and CO3Ap/PCL-coated α-TCP foams indicating an excellent biocompatibility. The incorporation of CO3Ap on the coating layer improved cellular attachment and accelerated proliferation. Thus, CO3Ap/PCL-coated α-TCP foam might be a promising candidate as implant material.
UR - http://www.scopus.com/inward/record.url?scp=84891616215&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84891616215&partnerID=8YFLogxK
U2 - 10.4028/www.scientific.net/AMR.858.7
DO - 10.4028/www.scientific.net/AMR.858.7
M3 - Conference contribution
AN - SCOPUS:84891616215
SN - 9783037859056
T3 - Advanced Materials Research
SP - 7
EP - 12
BT - Frontiers in Materials and Minerals Engineering
T2 - 5th Regional Conference on Materials Engineering and the 5th Regional Conference on Natural Resources and Materials 2013, RCM5 and RCNRM5 2013
Y2 - 22 January 2013 through 23 January 2013
ER -