Body mass index and stroke incidence in a Japanese community: The Hisayama study

Koji Yonemoto, Yasufumi Doi, Jun Hata, Toshiharu Ninomiya, Masayo Fukuhara, Fumie Ikeda, Naoko Mukai, Mitsuo Iida, Yutaka Kiyohara

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


Although obesity is one of the major risk factors for coronary heart disease, its role in the development of stroke remains controversial. A total of 2421 residents, aged 40-79 years of a Japanese community were followed up prospectively for 12 years. The subjects were divided into four groups according to body mass index (BMI) levels (<21.0, 21.0-22.9, 23.0-24.9 and 2≥5.0 kg m-2). During the follow-up, 107 ischemic and 51 hemorrhagic strokes occurred. The age-adjusted incidence of ischemic stroke for men significantly increased with increasing BMI levels (P for trend0.005). This association remained substantially unchanged even after adjustment for other risk factors: namely, systolic blood pressure, electrocardiogram abnormalities, diabetes, total cholesterol, high-density lipoprotein-cholesterol, triglycerides, smoking habits, alcohol intake and regular exercise (P for trend0.001). Compared with that of the BMI levels of ≥21.0 kg m-2, the multivariate-adjusted risk of ischemic stroke was significant even in the BMI levels of ≥23.0-24.9 kg m-2 (multivariate-adjusted hazard ratio (HR)3.12; 95% confidence interval (CI), 1.24-7.87; P<0.02) as well as in the BMI levels of 25 kg m 2 (multivariate-adjusted HR5.59; 95% CI, 2.09-14.91; P<0.001). In stratified analyses, the risk of ischemic stroke for men synergistically increased in subjects having both obesity and diabetes or a smoking habit. We found no significant associations between BMI levels and ischemic stroke in women and between BMI levels and hemorrhagic stroke in either sex. In conclusion, our findings suggest that overweight and obesity are independent risk factors for ischemic stroke in Japanese men.

Original languageEnglish
Pages (from-to)274-279
Number of pages6
JournalHypertension Research
Issue number2
Publication statusPublished - Feb 2011

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Body mass index and stroke incidence in a Japanese community: The Hisayama study'. Together they form a unique fingerprint.

Cite this