Blood compatibility of organic-inorganic biomedical materials

Akiyoshi Osaka, Tomohiko Yoshioka, Takeshi Yabuta, Kanji Tsuru, Satoshi Hayakawa

Research output: Contribution to journalArticlepeer-review


Organic-inorganic hybrids involving Ti-O bonds were coated on stainless-steel (SUS316L) substrates. Tetraisopropoxide and titanium methacrylate triisopropoxide were employed as the major starting chemicals to provide TiO2-polydimethylsiloxane (PDMS) layers or organotitanium molecular thin layers, respectively. Fourier transform infrared spectra indicated that each layer contained Ti-O bonds in their structure. The obtained hybrid layers had little effects on the blood-clotting times such as active partial thromboplastin time and pro thrombin time. In addition, the number of adhered platelet on the TiO2-PDMS layers depended on the composition, while the organotitanium molecular thin layers suppressed fibrinogen adsorption compared with coating-free SUS 316L substrate.

Original languageEnglish
Pages (from-to)713-716
Number of pages4
JournalKey Engineering Materials
Publication statusPublished - 2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Materials Science
  • Mechanics of Materials
  • Mechanical Engineering


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