Bisphenol A (BPA) and cell signaling pathways

Masaharu Murata, Jeong Hun Kang

Research output: Contribution to journalReview articlepeer-review

212 Citations (Scopus)


Bisphenol A (BPA; 4,4′-isopropylidenediphenol) is an endocrine disruptor that is used as a material for the production of phenol resins, polyacrylates, polyesters, epoxy resins, and polycarbonate plastics. Endocrine-disruptive or toxic effects of BPA on living organisms through a number of cell signaling pathways have been reported. BPA induces carcinogenesis, reproductive toxicity, abnormal inflammatory or immune response, and developmental disorders of brain or nervous system through various cell signaling pathways. This review considers the literature concerning BPA and its association with cancer-related cell signaling pathways, reproductive toxicity-related cell signaling pathways, inflammatory or immune response-related cell signaling pathways, and brain and nervous system-related cell signaling pathways.

Original languageEnglish
Pages (from-to)311-327
Number of pages17
JournalBiotechnology Advances
Issue number1
Publication statusPublished - Jan 2018

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology


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