TY - JOUR
T1 - Bisphenol A (BPA) and cell signaling pathways
AU - Murata, Masaharu
AU - Kang, Jeong Hun
N1 - Funding Information:
We would like to thank Dr. R. Toita and Dr. T. Kawano for their helpful comments and discussions. This work was supported by JSPS KAKENHI Grant Numbers JP15H03007 .
Publisher Copyright:
© 2017 Elsevier Inc.
PY - 2018/1
Y1 - 2018/1
N2 - Bisphenol A (BPA; 4,4′-isopropylidenediphenol) is an endocrine disruptor that is used as a material for the production of phenol resins, polyacrylates, polyesters, epoxy resins, and polycarbonate plastics. Endocrine-disruptive or toxic effects of BPA on living organisms through a number of cell signaling pathways have been reported. BPA induces carcinogenesis, reproductive toxicity, abnormal inflammatory or immune response, and developmental disorders of brain or nervous system through various cell signaling pathways. This review considers the literature concerning BPA and its association with cancer-related cell signaling pathways, reproductive toxicity-related cell signaling pathways, inflammatory or immune response-related cell signaling pathways, and brain and nervous system-related cell signaling pathways.
AB - Bisphenol A (BPA; 4,4′-isopropylidenediphenol) is an endocrine disruptor that is used as a material for the production of phenol resins, polyacrylates, polyesters, epoxy resins, and polycarbonate plastics. Endocrine-disruptive or toxic effects of BPA on living organisms through a number of cell signaling pathways have been reported. BPA induces carcinogenesis, reproductive toxicity, abnormal inflammatory or immune response, and developmental disorders of brain or nervous system through various cell signaling pathways. This review considers the literature concerning BPA and its association with cancer-related cell signaling pathways, reproductive toxicity-related cell signaling pathways, inflammatory or immune response-related cell signaling pathways, and brain and nervous system-related cell signaling pathways.
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U2 - 10.1016/j.biotechadv.2017.12.002
DO - 10.1016/j.biotechadv.2017.12.002
M3 - Review article
C2 - 29229539
AN - SCOPUS:85037740314
SN - 0734-9750
VL - 36
SP - 311
EP - 327
JO - Biotechnology Advances
JF - Biotechnology Advances
IS - 1
ER -
