Biosynthetic studies of the tetramic acid antibiotic trichosetin

Eufrocinio C. Marfori, Takeshi Bamba, Shin Ichiro Kajiyama, Ei Ichiro Fukusaki, Akio Kobayashi

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)


A feeding experiment with 13C-labeled precursors was conducted in the dual cultures of Trichoderma harzianum H14 and Catharanthus roseus callus to determine the biosynthetic origin of the carbon atoms in trichosetin. Results showed that trichosetin originated from two separate biogenetic units. One unit is an octaketide intermediate directly derived from eight intact acetate units joined in a head-to-tail fashion of a polyketide pathway. The other unit is serine.

Original languageEnglish
Pages (from-to)6655-6658
Number of pages4
Issue number33
Publication statusPublished - Aug 12 2002
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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