Bioorganometallic B12 as Versatile Catalyst for Green Organic Synthesis

Hisashi Shimakoshi, Yoshio Hisaeda

Research output: Chapter in Book/Report/Conference proceedingChapter


Bioorganometallic compounds were utilized as catalysts for various molecular transformations. Among the bioorganometallic compounds, coenzyme B12 is a well-known example of the B12-dependent reaction. Using the unique property of the B12 complex, various catalytic reactions have been developed. The B12 complex-photosensitizer composites have become an efficient catalyst for light-driven molecular transformations. The B12-dependent enzymes mimic reactions, such as the dechlorination of organic halides and the radical mediated isomerization reactions, catalytically occurring using the B12 complex-photosensitizer composites. In addition to the B12-mimic reaction, novel bioinspired reactions were also developed, such as hydrogen production or alkene and alkyne reductions, and the cobalt-hydrogen complex was considered as a putative intermediate of the reactions. Electroorganic syntheses mediated by the B12 complex have been also developed as green molecular transformations. The redox active B12 complex shows a unique catalysis in organic synthesis.

Original languageEnglish
Title of host publicationAdvances in Bioorganometallic Chemistry
Number of pages20
ISBN (Electronic)9780128141984
ISBN (Print)9780128141977
Publication statusPublished - Dec 6 2018

All Science Journal Classification (ASJC) codes

  • Chemistry(all)


Dive into the research topics of 'Bioorganometallic B12 as Versatile Catalyst for Green Organic Synthesis'. Together they form a unique fingerprint.

Cite this