Bioorganometallic B12 as Versatile Catalyst for Green Organic Synthesis

Bioorganometallic compounds were utilized as catalysts for various molecular transformations. Among the bioorganometallic compounds, coenzyme B₁₂ is a well-known example of the B₁₂-dependent reaction. Using the unique property of the B₁₂ complex, various catalytic reactions have been developed. The B₁₂ complex-photosensitizer composites have become an efficient catalyst for light-driven molecular transformations. The B₁₂-dependent enzymes mimic reactions, such as the dechlorination of organic halides and the radical mediated isomerization reactions, catalytically occurring using the B₁₂ complex-photosensitizer composites. In addition to the B₁₂-mimic reaction, novel bioinspired reactions were also developed, such as hydrogen production or alkene and alkyne reductions, and the cobalt-hydrogen complex was considered as a putative intermediate of the reactions. Electroorganic syntheses mediated by the B₁₂ complex have been also developed as green molecular transformations. The redox active B₁₂ complex shows a unique catalysis in organic synthesis.