Biomimetic synthesis of α-amino acids from α-keto acids

Seiji Shinkai; Hisatake Hamada; Akihiko Dohyama; Osamu Manabe

doi:10.1016/S0040-4039(00)77779-3

Biomimetic synthesis of α-amino acids from α-keto acids

Seiji Shinkai, Hisatake Hamada, Akihiko Dohyama, Osamu Manabe

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Protonated α-imino acids, RC(=NH₂⁺)COOH, were easily reduced to α-amino acids by an acid-stable NADH analogue, 1-benzyl-3-carbamoyl-1,4-dihydroquinoline. This is the first model reaction of NADH-mediated α-amino acid synthesis from α-keto acids.

Original language	English
Pages (from-to)	1661-1664
Number of pages	4
Journal	Tetrahedron Letters
Volume	21
Issue number	17
DOIs	https://doi.org/10.1016/S0040-4039(00)77779-3
Publication status	Published - 1980
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

Access to Document

10.1016/S0040-4039(00)77779-3

Cite this

@article{7eddbf1f1bee4cf7a68fea9231703c5b,

title = "Biomimetic synthesis of α-amino acids from α-keto acids",

abstract = "Protonated α-imino acids, RC(=NH2+)COOH, were easily reduced to α-amino acids by an acid-stable NADH analogue, 1-benzyl-3-carbamoyl-1,4-dihydroquinoline. This is the first model reaction of NADH-mediated α-amino acid synthesis from α-keto acids.",

author = "Seiji Shinkai and Hisatake Hamada and Akihiko Dohyama and Osamu Manabe",

year = "1980",

doi = "10.1016/S0040-4039(00)77779-3",

language = "English",

volume = "21",

pages = "1661--1664",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Limited",

number = "17",

}

TY - JOUR

T1 - Biomimetic synthesis of α-amino acids from α-keto acids

AU - Shinkai, Seiji

AU - Hamada, Hisatake

AU - Dohyama, Akihiko

AU - Manabe, Osamu

PY - 1980

Y1 - 1980

N2 - Protonated α-imino acids, RC(=NH2+)COOH, were easily reduced to α-amino acids by an acid-stable NADH analogue, 1-benzyl-3-carbamoyl-1,4-dihydroquinoline. This is the first model reaction of NADH-mediated α-amino acid synthesis from α-keto acids.

AB - Protonated α-imino acids, RC(=NH2+)COOH, were easily reduced to α-amino acids by an acid-stable NADH analogue, 1-benzyl-3-carbamoyl-1,4-dihydroquinoline. This is the first model reaction of NADH-mediated α-amino acid synthesis from α-keto acids.

UR - http://www.scopus.com/inward/record.url?scp=0442269039&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0442269039&partnerID=8YFLogxK

U2 - 10.1016/S0040-4039(00)77779-3

DO - 10.1016/S0040-4039(00)77779-3

M3 - Article

AN - SCOPUS:0442269039

SN - 0040-4039

VL - 21

SP - 1661

EP - 1664

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 17

ER -

Biomimetic synthesis of α-amino acids from α-keto acids

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this