Biologically selective potassium channel openers having 1,1- diethylpropyl group

Kazuya Yoshiizumi; Norihiko Seko; Noriyasu Nishimura; Shoji Ikeda; Kohichiro Yoshino; Hirosato Kondo; Kazutaka Tanizawa

doi:10.1016/S0960-894X(98)00625-8

Biologically selective potassium channel openers having 1,1- diethylpropyl group

Kazuya Yoshiizumi, Norihiko Seko, Noriyasu Nishimura, Shoji Ikeda, Kohichiro Yoshino, Hirosato Kondo, Kazutaka Tanizawa

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

To find out selective potassium channel openers (PCOs), we synthesized several 3,5-disubstituted phenylcyanoguanidine derivatives and investigated their structure-activity relationships (SAR). As a result, we discovered selective PCOs having 1,1-diethylpropyl group toward antihypertensive activity.

Original language	English
Pages (from-to)	3397-3402
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	8
Issue number	23
DOIs	https://doi.org/10.1016/S0960-894X(98)00625-8
Publication status	Published - Dec 1 1998
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(98)00625-8

Cite this

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title = "Biologically selective potassium channel openers having 1,1- diethylpropyl group",

abstract = "To find out selective potassium channel openers (PCOs), we synthesized several 3,5-disubstituted phenylcyanoguanidine derivatives and investigated their structure-activity relationships (SAR). As a result, we discovered selective PCOs having 1,1-diethylpropyl group toward antihypertensive activity.",

author = "Kazuya Yoshiizumi and Norihiko Seko and Noriyasu Nishimura and Shoji Ikeda and Kohichiro Yoshino and Hirosato Kondo and Kazutaka Tanizawa",

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T1 - Biologically selective potassium channel openers having 1,1- diethylpropyl group

AU - Yoshiizumi, Kazuya

AU - Seko, Norihiko

AU - Nishimura, Noriyasu

AU - Ikeda, Shoji

AU - Yoshino, Kohichiro

AU - Kondo, Hirosato

AU - Tanizawa, Kazutaka

PY - 1998/12/1

Y1 - 1998/12/1

N2 - To find out selective potassium channel openers (PCOs), we synthesized several 3,5-disubstituted phenylcyanoguanidine derivatives and investigated their structure-activity relationships (SAR). As a result, we discovered selective PCOs having 1,1-diethylpropyl group toward antihypertensive activity.

AB - To find out selective potassium channel openers (PCOs), we synthesized several 3,5-disubstituted phenylcyanoguanidine derivatives and investigated their structure-activity relationships (SAR). As a result, we discovered selective PCOs having 1,1-diethylpropyl group toward antihypertensive activity.

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U2 - 10.1016/S0960-894X(98)00625-8

DO - 10.1016/S0960-894X(98)00625-8

M3 - Article

C2 - 9873741

AN - SCOPUS:0032401163

SN - 0960-894X

VL - 8

SP - 3397

EP - 3402

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 23

ER -

Biologically selective potassium channel openers having 1,1- diethylpropyl group

Abstract

All Science Journal Classification (ASJC) codes

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