Biologically selective potassium channel openers having 1,1- diethylpropyl group

Kazuya Yoshiizumi, Norihiko Seko, Noriyasu Nishimura, Shoji Ikeda, Kohichiro Yoshino, Hirosato Kondo, Kazutaka Tanizawa

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


To find out selective potassium channel openers (PCOs), we synthesized several 3,5-disubstituted phenylcyanoguanidine derivatives and investigated their structure-activity relationships (SAR). As a result, we discovered selective PCOs having 1,1-diethylpropyl group toward antihypertensive activity.

Original languageEnglish
Pages (from-to)3397-3402
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Issue number23
Publication statusPublished - Dec 1 1998
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


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