Biological applications of magnetic nanoparticles-for magnetic immunoassay and magnetic particle imaging

T. Yoshida; T. Sasayama; K. Enpuku

doi:10.1149/07502.0039ecst

Biological applications of magnetic nanoparticles-for magnetic immunoassay and magnetic particle imaging

T. Yoshida, T. Sasayama, K. Enpuku

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2 Citations (Scopus)

Abstract

Here, we introduce the application of magnetic nanoparticles (MNPs) for magnetic immunoassay and magnetic particle imaging (MPI). First, we present a liquid-phase magnetic immunoassay system that uses the difference in Brownian relaxation between bound and unbound magnetic particles. We found that the minimum detectable molecular number concentration of the developed magnetic immunoassay system is 3.6 × 10-18 mol/mL. We then studied the effect of the alignment of the easy axes on the performance of the MPI. Although the detection sensitivity can be improved by using an aligned MNP sample, the spatial resolution of the aligned sample strongly depends on the direction of alignment of the easy axes.

Original language	English
Title of host publication	Magnetic Materials Processes and Devices 14
Editors	C. Bonhote, G. Zangari, Y. Kitamoto, T. Osaka, H. H. Gatzen
Publisher	Electrochemical Society Inc.
Pages	39-47
Number of pages	9
Edition	2
ISBN (Electronic)	9781607687191, 9781607687672, 9781607687689, 9781607687696, 9781607687702, 9781607687719, 9781607687726, 9781607687733, 9781607687740, 9781607687757, 9781607687771, 9781607687788, 9781607687795, 9781607687801, 9781607687818, 9781607687825, 9781607687832, 9781607687849, 9781607687856, 9781607687863, 9781607687887, 9781607687894, 9781607687900, 9781607687917, 9781607687924, 9781607687931, 9781607687948, 9781607687955, 9781607687962, 9781607687979, 9781607687986, 9781607687993, 9781607688006, 9781607688013, 9781607688020, 9781607688037
DOIs	https://doi.org/10.1149/07502.0039ecst
Publication status	Published - 2016
Event	Symposium on Magnetic Materials Processes and Devices 14 - PRiME 2016/230th ECS Meeting - Honolulu, United States Duration: Oct 2 2016 → Oct 7 2016

Publication series

Name	ECS Transactions
Number	2
Volume	75
ISSN (Print)	1938-6737
ISSN (Electronic)	1938-5862

Other

Other	Symposium on Magnetic Materials Processes and Devices 14 - PRiME 2016/230th ECS Meeting
Country/Territory	United States
City	Honolulu
Period	10/2/16 → 10/7/16

All Science Journal Classification (ASJC) codes

Engineering(all)

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10.1149/07502.0039ecst

Cite this

Yoshida, T., Sasayama, T., & Enpuku, K. (2016). Biological applications of magnetic nanoparticles-for magnetic immunoassay and magnetic particle imaging. In C. Bonhote, G. Zangari, Y. Kitamoto, T. Osaka, & H. H. Gatzen (Eds.), Magnetic Materials Processes and Devices 14 (2 ed., pp. 39-47). (ECS Transactions; Vol. 75, No. 2). Electrochemical Society Inc.. https://doi.org/10.1149/07502.0039ecst

Biological applications of magnetic nanoparticles-for magnetic immunoassay and magnetic particle imaging. / Yoshida, T.; Sasayama, T.; Enpuku, K.
Magnetic Materials Processes and Devices 14. ed. / C. Bonhote; G. Zangari; Y. Kitamoto; T. Osaka; H. H. Gatzen. 2. ed. Electrochemical Society Inc., 2016. p. 39-47 (ECS Transactions; Vol. 75, No. 2).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Yoshida, T , Sasayama, T & Enpuku, K 2016, Biological applications of magnetic nanoparticles-for magnetic immunoassay and magnetic particle imaging. in C Bonhote, G Zangari, Y Kitamoto, T Osaka & HH Gatzen (eds), Magnetic Materials Processes and Devices 14. 2 edn, ECS Transactions, no. 2, vol. 75, Electrochemical Society Inc., pp. 39-47, Symposium on Magnetic Materials Processes and Devices 14 - PRiME 2016/230th ECS Meeting, Honolulu, United States, 10/2/16. https://doi.org/10.1149/07502.0039ecst

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AB - Here, we introduce the application of magnetic nanoparticles (MNPs) for magnetic immunoassay and magnetic particle imaging (MPI). First, we present a liquid-phase magnetic immunoassay system that uses the difference in Brownian relaxation between bound and unbound magnetic particles. We found that the minimum detectable molecular number concentration of the developed magnetic immunoassay system is 3.6 × 10-18 mol/mL. We then studied the effect of the alignment of the easy axes on the performance of the MPI. Although the detection sensitivity can be improved by using an aligned MNP sample, the spatial resolution of the aligned sample strongly depends on the direction of alignment of the easy axes.

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Biological applications of magnetic nanoparticles-for magnetic immunoassay and magnetic particle imaging

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