TY - JOUR
T1 - Biological Activity of Optically Active Salithion and Salioxon
AU - Hirashima, Akinori
AU - Ishaaya, Isaac
AU - Ueno, Ryohei
AU - Ichiyama, Yoshifumi
AU - Wu, Shao Yong
AU - Eto, Morifusa
N1 - Funding Information:
Acknowledgments. This work was supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan. We thank Kazuhiko Oyama and Ryuko Takeya in this laboratory for their skillful technical assistance.
PY - 1989
Y1 - 1989
N2 - Salioxon enantiomers were obtained from salithion enantiomers by MCPBA oxidation. The larvicidal and adulticidal activities of salithion enantiomers, and the anti-cholinesterase activity of salioxon enantiomers were determined on house flies. On larvae, the potency of (S)(-)-salithion (LC50=1.1 ppm) was about two-fold higher than the (R)(+)-enantiomer (LC50 = 2.1 ppm). A similar ratio was obtained when these compounds were applied topically to female adults. The relative potency of these enantiomers correlated well with the anti-cholinesterase activity of their respective oxidative enantiomers, (R)(+)-and (S)(-)-salioxon, which are assumed to have been formed after their application to the insects.
AB - Salioxon enantiomers were obtained from salithion enantiomers by MCPBA oxidation. The larvicidal and adulticidal activities of salithion enantiomers, and the anti-cholinesterase activity of salioxon enantiomers were determined on house flies. On larvae, the potency of (S)(-)-salithion (LC50=1.1 ppm) was about two-fold higher than the (R)(+)-enantiomer (LC50 = 2.1 ppm). A similar ratio was obtained when these compounds were applied topically to female adults. The relative potency of these enantiomers correlated well with the anti-cholinesterase activity of their respective oxidative enantiomers, (R)(+)-and (S)(-)-salioxon, which are assumed to have been formed after their application to the insects.
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U2 - 10.1271/bbb1961.53.175
DO - 10.1271/bbb1961.53.175
M3 - Article
AN - SCOPUS:85007746384
SN - 0002-1369
VL - 53
SP - 175
EP - 178
JO - Agricultural and Biological Chemistry
JF - Agricultural and Biological Chemistry
IS - 1
ER -