Biological activity of optically active salithion and salioxon

Akinori Hirashima, Isaac Ishaaya, Ryohei Ueno, Yoshifumi Ichiyama, Shao Yong Wu, Morifusa Eto

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24 Citations (Scopus)


Salioxon enantiomers were obtained from salithion enantiomers by MCPBA oxidation. The larvicidal and adulticidal activities of salithion enantiomers, and the anti-cholinesterase activity of salioxon enantiomers were determined on house flies. On larvae, the potency of (S)(-)-salithion (LC50 = 1.1 ppm) was about two-fold higher than the (R)(+)-enantiomer (LC50 = 2.1 ppm). A similar ratio was obtained when these compounds were applied topically to female adults. The relative potency of these enantiomers correlated well with the anti-cholinesterase activity of their respective oxidative enantiomers, (R)(+)-and (S)(-)-salioxon, which are assumed to have been formed after their application to the insects.

Original languageEnglish
Pages (from-to)175-178
Number of pages4
JournalAgricultural and Biological Chemistry
Issue number1
Publication statusPublished - Jan 1989

All Science Journal Classification (ASJC) codes

  • General Biochemistry,Genetics and Molecular Biology
  • General Agricultural and Biological Sciences


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