TY - JOUR
T1 - Bioinspired Perfluorocarbon-Based Oxygen Carriers with Concave Shape and Deformable Shell
AU - Fu, Xiaoting
AU - Ohta, Seiichi
AU - Kawakatsu, Takahiro
AU - Kamihira, Masamichi
AU - Sakai, Yasuyuki
AU - Ito, Taichi
N1 - Funding Information:
This work was supported by JSPS KAKENHI Grant Number JP2365648. The authors thank Corbion Biomaterials, Nomura Jimusho, Inc., Mitsui Chemicals Inc., and Soken Chemical & Engineering Co., Ltd. for kindly providing PLC, PLGA, and acrylic beads, respectively. The authors also thank Shimadzu Corp. for kindly providing compression and AFM measurement. X.T.F. is grateful to the Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT) for the financial support.
Funding Information:
This work was supported by JSPS KAKENHI Grant Number JP2365648. The authors thank Corbion Biomaterials, Nomura Jimusho, Inc., Mitsui Chemicals Inc., and Soken Chemical & Engineering Co., Ltd. for kindly providing PLC, PLGA, and acrylic beads, respectively. The authors also thank Shimadzu Corp. for kindly providing compression and AFM measurement. X.T.F. is grateful to the Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT) for the financial support.
Publisher Copyright:
© 2021 Wiley-VCH GmbH.
PY - 2022/3
Y1 - 2022/3
N2 - Human red blood cells (hRBCs) possess a unique biconcave structure with a highly deformable cell membrane and condensed cytosol hemoglobin for oxygen delivery. Inspired by hRBCs, novel deformable core-shell particles are developed as perfluorocarbon-based oxygen carriers (OCs), called “cDFCs” (concave-shaped deformable PFC-based OCs), using the Shirasu porous glass (SPG) membrane emulsification technique. cDFCs have a perfluorooctyl bromide core of high oxygen solubility and poly(lactide-co-caprolactone) shell, which is thin and highly deformable. They have an optical equivalent diameter of 7.9 ± 2.5 µm and a unique concave shape. Owing to their low Young's modulus (93 kPa) and their diameter and shape, they successfully pass through a 4.5-µm-gap silicon microchannel as a blood capillary model. Enhanced oxygen supply to multiple layered cells is demonstrated under hypoxic conditions, indicating their efficiency as OCs. cDFCs are new potential OCs in tissue engineering and blood substitution in the future.
AB - Human red blood cells (hRBCs) possess a unique biconcave structure with a highly deformable cell membrane and condensed cytosol hemoglobin for oxygen delivery. Inspired by hRBCs, novel deformable core-shell particles are developed as perfluorocarbon-based oxygen carriers (OCs), called “cDFCs” (concave-shaped deformable PFC-based OCs), using the Shirasu porous glass (SPG) membrane emulsification technique. cDFCs have a perfluorooctyl bromide core of high oxygen solubility and poly(lactide-co-caprolactone) shell, which is thin and highly deformable. They have an optical equivalent diameter of 7.9 ± 2.5 µm and a unique concave shape. Owing to their low Young's modulus (93 kPa) and their diameter and shape, they successfully pass through a 4.5-µm-gap silicon microchannel as a blood capillary model. Enhanced oxygen supply to multiple layered cells is demonstrated under hypoxic conditions, indicating their efficiency as OCs. cDFCs are new potential OCs in tissue engineering and blood substitution in the future.
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U2 - 10.1002/admt.202100573
DO - 10.1002/admt.202100573
M3 - Article
AN - SCOPUS:85116763738
SN - 2365-709X
VL - 7
JO - Advanced Materials Technologies
JF - Advanced Materials Technologies
IS - 3
M1 - 2100573
ER -