Bioenergy status of human liver during and after warm ischemia

T. Kanematsu, H. Higashi, K. Takenaka, T. Matsumata, Y. Maehara, K. Sugimachi

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Changes in the human liver's cellular bioenergy status during warm ischaemia and the subsequent blood reflow period were investigated by means of adenosine triphosphate (ATP) assay. In 8 patients, the average level of ATP in the liver tissue decreased significantly (p < 0.05) from 28.7 ± 8.6 μmol/g protein to 19.1 ± 8.7 μmol/g protein within 10 minutes of warm ischaemia. The pattern of decline in ATP levels did not correlate with clinical parameters, including presence of cirrhosis, liver function, type of ischaemic method employed and postoperative complications. After reperfusion, ATP levels increased rapidly from 15.1 ± 8.9 μmol/g protein to 19.6 ± 8.2 μmol/g protein within 10 minutes, a1though the difference was not statistically significant. These patients' postoperative course was uneventful, and the results of serum chemistry tests were normal. The present study demonstrates a direct correlation between the levels of tissue ATP and the status of the liver's blood supply.

Original languageEnglish
Pages (from-to)160-162
Number of pages3
Issue numberSUPPL. 2
Publication statusPublished - 1990
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology


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