Biocompatibility of tetracalcium phosphate cement when used as a bone substitute

Y. Yoshimine, A. Akamine, M. Mukai, K. Maeda, M. Matsukura, Y. Kimura, T. Makishima

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)


We evaluated the biocompatibility of tetracalcium phosphate (4CP) cement, made of 4CP powder and 40 wt% copolymer of polyacrylic acid/itaconic acid and 10 wt% citric acid solution. Light and electron microscopic characteristics were studied 3, 10 and 30 d after implantation. Neither inflammation nor foreign-body giant cell reaction was observed in the tissue adjacent to the implanted material. After 30 d, this material was surrounded with newly formed bone. Ultrastructural examination showed that osteogenesis occurred directly on the surface of the material. These findings suggest that this 4CP cement is biocompatible and possesses osteoconductive properties.

Original languageEnglish
Pages (from-to)403-406
Number of pages4
Issue number6
Publication statusPublished - May 1993

All Science Journal Classification (ASJC) codes

  • Mechanics of Materials
  • Ceramics and Composites
  • Bioengineering
  • Biophysics
  • Biomaterials


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