Biochemical switching device: how to turn on (off) the switch

Masahiro Okamoto, Toshio Sakai, Katsuya Hayashi

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


We previously showed with computer simulations that cyclic enzyme systems have the reliability of ON-OFF types of operation (McCulloch-Pitts' neuronic equation) and the applicability for a switching circuit in a biocomputer. The switching time was inevitably determined in accordance with the difference in amount between two inputs of the system. This characteristic is, however, a disadvantage for practical use of a switching device; we need to improve the system in order for the switching time to optionally be changed. We shall present here how to turn on (off) the switch independently of the modes of two inputs. By introducing pulse perturbation, we could optionally set up the switching time of a cyclic enzyme system (biochemical switching device).

Original languageEnglish
Pages (from-to)155-162
Number of pages8
Issue number2
Publication statusPublished - 1989
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Statistics and Probability
  • Modelling and Simulation
  • General Biochemistry,Genetics and Molecular Biology
  • Applied Mathematics


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