Biochemical and molecular mechanisms in the development of diabetic vascular complications

George L. King, Makoto Kunisaki, Yoshihiko Nishio, Toyoshi Inoguchi, Teruo Shiba, Pu Xia

Research output: Contribution to journalArticlepeer-review

117 Citations (Scopus)


Hyperglycemia is the major causal factor in the development of diabetic vascular complications. The mechanism by which hyperglycemia causes the complications is not clear; however, it is very likely that hyperglycemia is mediating its adverse effects through multiple mechanisms. We have summarized some of these mechanisms in this review, with particular attention to the effect of hyperglycemia on the activation of diacylglycerol (DAG)-protein kinase C (PKC) pathway. We have reviewed existing information regarding various vascular tissues that show increased DAG and PKC levels. In addition, the mechanism by which hyperglycemia increases DAG as well as the cellular physiological consequences on the activation of PKC have been reviewed.

Original languageEnglish
Pages (from-to)S105-S108
Issue number3 SUPPL.
Publication statusPublished - 1996
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism


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