TY - JOUR
T1 - Bioactivity of sol-gel derived organically modified silicates. Part I
T2 - In vitro examination
AU - Tsuru, K.
AU - Ohtsuki, C.
AU - Osaka, A.
AU - Iwamoto, T.
AU - Mackenzie, J. D.
N1 - Funding Information:
Financial support by Grant-in-Aid for Scientific Research (C-07680944, 1995), the Ministry of Education, Culture, Science, and Sports, Japan is greatefully acknowledged.
PY - 1997/3
Y1 - 1997/3
N2 - Bioactivity was investigated for several organically modified silicates (Ormosils) prepared through sol-gel processes. Ca(II)-free samples were biocompatible only, but Ca(II) containing samples were bioactive and deposited apatite during immersion in a simulated body fluid. The ease of silanol (Si-OH) group formation on the ormosils was considered a predominant factor controlling the bioactivity, while the effect of dissolved Ca(II) ions to increase the degree of supersaturation in the simulated body fluid is secondary.
AB - Bioactivity was investigated for several organically modified silicates (Ormosils) prepared through sol-gel processes. Ca(II)-free samples were biocompatible only, but Ca(II) containing samples were bioactive and deposited apatite during immersion in a simulated body fluid. The ease of silanol (Si-OH) group formation on the ormosils was considered a predominant factor controlling the bioactivity, while the effect of dissolved Ca(II) ions to increase the degree of supersaturation in the simulated body fluid is secondary.
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U2 - 10.1023/A:1018523203667
DO - 10.1023/A:1018523203667
M3 - Article
C2 - 15348769
AN - SCOPUS:0031106869
SN - 0957-4530
VL - 8
SP - 157
EP - 161
JO - Journal of Materials Science: Materials in Medicine
JF - Journal of Materials Science: Materials in Medicine
IS - 3
ER -