Bio and nanotechnological strategies for tumor-targeted gene therapy

Jeong Hun Kang, Riki Toita, Yoshiki Katayama

    Research output: Contribution to journalReview articlepeer-review

    22 Citations (Scopus)


    Gene therapy is a new medical approach for the treatment of tumors. For safe and efficient gene therapy, therapeutic genes need to be delivered efficiently into the target tumor cells. Development of gene delivery systems to specifically recognize and target tumor cells and to distinguish them from normal cells, especially in the same tissue or organ, is one of the most important issues regarding the present gene delivery methodologies. The enhanced permeability and retention (EPR) effect using the characteristics of angiogenic tumor blood vessels, as well as gene delivery systems recognizing hyperactivated receptors or intracellular signals, is broadly applied to tumor-targeted gene therapy. In addition, bacterial vectors can be a useful means for targeting hypoxic or anoxic regions of a tumor.

    Original languageEnglish
    Pages (from-to)757-763
    Number of pages7
    JournalBiotechnology Advances
    Issue number6
    Publication statusPublished - Nov 2010

    All Science Journal Classification (ASJC) codes

    • Biotechnology
    • Bioengineering
    • Applied Microbiology and Biotechnology


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