Beta-blocker use at discharge in patients hospitalized for heart failure is associated with improved survival

Miyuki Tsuchihashi-Makaya, Shintaro Kinugawa, Hisashi Yokoshiki, Sanae Hamaguchi, Takashi Yokota, Daisuke Goto, Kazutomo Goto, Akira Takeshita, Hiroyuki Tsutsui

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31 Citations (Scopus)


Background: Previous studies demonstrated that β-blocker use at the time of hospital discharge significantly increased postdischarge treatment rates, associated with an early (60- to 90-day) survival benefit in patients with heart failure (HF). However, it is unknown whether this therapeutic approach can also improve the long-term survival. We thus examined the long-term effects of β-blocker use at discharge on outcomes in patients hospitalized for HF and left ventricular systolic dysfunction (LVSD) (ejection fraction <40%). Methods and Results: The Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD) enrolled HF patients hospitalized with worsening symptoms and they were followed during an average of 2.2 years. A total of 947 patients had LVSD, among whom 624 (66%) were eligible to receive a β-blocker at discharge. After adjustment for covariate and propensity score, discharge use of β-blocker, when compared to no β-blocker use, was associated with a significant reduced risk of all-cause mortality (hazard ratio (HR) 0.564, 95% confidence interval (CI) 0.358-0.889, P=0.014) and cardiac mortality (HR 0.489, 95%CI 0.279-0.859, P=0.013) after hospital discharge. Conclusions: β-blocker use at the time of discharge was associated with a long-term survival benefit in a diverse cohort of patients hospitalized with HF.

Original languageEnglish
Pages (from-to)1364-1371
Number of pages8
JournalCirculation Journal
Issue number7
Publication statusPublished - 2010

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine


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