Beta 3-adrenergic receptor is involved in feeding regulation in chicks

Tetsuya Tachibana, Tomo Takagi, Ei Suke Saito, Shozo Tomonaga, Rong Zhang, Yusuke Koga, Yasuhiro Kido, Donald Michael Denbow, Mitsuhiro Furuse

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11 Citations (Scopus)


We examined whether the brain beta 3-adrenergic receptor (B3-AR) is involved in the feeding regulation of chicks. Intracerebroventricular (ICV) injection of BRL37344, a B3-AR agonist, reduced food intake of chicks under ad libitum, but not fasting, feeding conditions. The ICV injection of BRL37344 did not affect chick posture or locomotion activity suggesting that BRL37344 inhibited feeding without induction of sleep-like behavior as caused by norepinephrine. Furthermore, the rectal temperature increased following the ICV injection of BRL37344. Intraperitoneal administration of BRL37344 did not reduce food intake under ad libitum feeding condition. The present study demonstrated that the brain B3-AR is involved in the inhibition of feeding in chicks. We also suggested that activation of the brain affects the energy metabolism in chicks.

Original languageEnglish
Pages (from-to)403-409
Number of pages7
JournalComparative Biochemistry and Physiology - A Molecular and Integrative Physiology
Issue number3
Publication statusPublished - Jul 1 2003

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Molecular Biology


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