TY - JOUR
T1 - Beneficial effects of preoperative lipiodolization for resectable large hepatocellular carcinoma (≥5 cm in diameter)
AU - Yamashita, Yo Ichi
AU - takeishi, kazuki
AU - Tsuijita, Eiji
AU - Yoshiya, Shouhei
AU - Morita, Kazutoyo
AU - Kayashima, Hiroto
AU - Iguchi, Tomohiro
AU - Taketomi, Akinobu
AU - Shirabe, Ken
AU - Maehara, Yoshihiko
PY - 2012/9/15
Y1 - 2012/9/15
N2 - Background The effects of preoperative lipiodolization (LPD) for large hepatocellular carcinoma (HCC) are controversial. Methods A retrospective review was undertaken for 137 patients with initial solitary resectable HCC ≥5 cm who underwent hepatic resection between 1995 and 2008. Forty-two patients underwent preoperative LPD, and clinical data and prognosis were compared to those of patients without preoperative LPD (na=95). Results Surgical results of the LPD group, such as surgical time, surgical blood loss, and the mortality and morbidity rate were statistically equal to those of the nonLPD group. The disease-free and overall survival of the LPD group were significantly better than those of the nonLPD group, and early tumor recurrence within 1-year of the LPD group was significantly lower than that of the nonLPD group. According to the multivariate analysis, the absence of preoperative LPD was an independent poor prognostic factor of patients with hepatic resection for HCC ≥5 cm. Conclusion Preoperative LPD suppressed early tumor recurrence and improved patient survival after hepatic resection for HCC ≥5 cm. J. Surg. Oncol. 2012; 106:498-503. © 2012 Wiley Periodicals, Inc.
AB - Background The effects of preoperative lipiodolization (LPD) for large hepatocellular carcinoma (HCC) are controversial. Methods A retrospective review was undertaken for 137 patients with initial solitary resectable HCC ≥5 cm who underwent hepatic resection between 1995 and 2008. Forty-two patients underwent preoperative LPD, and clinical data and prognosis were compared to those of patients without preoperative LPD (na=95). Results Surgical results of the LPD group, such as surgical time, surgical blood loss, and the mortality and morbidity rate were statistically equal to those of the nonLPD group. The disease-free and overall survival of the LPD group were significantly better than those of the nonLPD group, and early tumor recurrence within 1-year of the LPD group was significantly lower than that of the nonLPD group. According to the multivariate analysis, the absence of preoperative LPD was an independent poor prognostic factor of patients with hepatic resection for HCC ≥5 cm. Conclusion Preoperative LPD suppressed early tumor recurrence and improved patient survival after hepatic resection for HCC ≥5 cm. J. Surg. Oncol. 2012; 106:498-503. © 2012 Wiley Periodicals, Inc.
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U2 - 10.1002/jso.23098
DO - 10.1002/jso.23098
M3 - Article
C2 - 22442003
AN - SCOPUS:84865122865
SN - 0022-4790
VL - 106
SP - 498
EP - 503
JO - Journal of Surgical Oncology
JF - Journal of Surgical Oncology
IS - 4
ER -