TY - JOUR
T1 - Behavioral and clinical correlates of high-sensitivity C-reactive protein in Japanese men and women
AU - Hirata, Akie
AU - Ohnaka, Keizo
AU - Morita, Makiko
AU - Toyomura, Kengo
AU - Kono, Suminori
AU - Yamamoto, Ken
AU - Adachi, Masahiro
AU - Kawate, Hisaya
AU - Takayanagi, Ryoichi
N1 - Funding Information:
This work was supported by a Grant-in-Aids for Scientific Research (A) (21249044) from the Japan Society of the Promotion of Science, Japan. The authors are grateful to the East Division of the Fukuoka City Medical Association for cordial support.
PY - 2012/10/1
Y1 - 2012/10/1
N2 - Background: Inflammation has been implicated in the pathogenesis of cardiovascular disease, type 2 diabetes mellitus and cancer. Serum concentration of high-sensitivity C-reactive protein is a good biomarker of chronic low-grade inflammation. Few studies have evaluated relative importance of behavioral and clinical covariates of high-sensitivity C-reactive protein in Japanese population. Methods: The study subjects were men and women aged 49-76 years from the cohort study of lifestyle-related diseases between February 2004 and July 2006. Analysis of covariance and multiple linear regression analysis were used to estimate geometric means of high-sensitivity C-reactive protein and trends of association. Results: Smoking, body mass index, hypertension, type 2 diabetes mellitus, elevated non-high density lipoprotein cholesterol, prudent dietary pattern were independently associated with serum high-sensitivity C-reactive protein in both men and women. High-sensitivity C-reactive protein concentrations were lowest in men with a moderate intake of alcohol (< 30 mL/day). In men, smoking and body mass index accounted for 28 % and 26 % of the variation in high-sensitivity C-reactive protein, respectively, while body mass index accounted for 60 % of the variation of high-sensitivity C-reactive protein in women. Conclusions: Smoking and body mass index in men, and body mass index in women, were major correlates of serum high-sensitivity C-reactive protein in Japanese people.
AB - Background: Inflammation has been implicated in the pathogenesis of cardiovascular disease, type 2 diabetes mellitus and cancer. Serum concentration of high-sensitivity C-reactive protein is a good biomarker of chronic low-grade inflammation. Few studies have evaluated relative importance of behavioral and clinical covariates of high-sensitivity C-reactive protein in Japanese population. Methods: The study subjects were men and women aged 49-76 years from the cohort study of lifestyle-related diseases between February 2004 and July 2006. Analysis of covariance and multiple linear regression analysis were used to estimate geometric means of high-sensitivity C-reactive protein and trends of association. Results: Smoking, body mass index, hypertension, type 2 diabetes mellitus, elevated non-high density lipoprotein cholesterol, prudent dietary pattern were independently associated with serum high-sensitivity C-reactive protein in both men and women. High-sensitivity C-reactive protein concentrations were lowest in men with a moderate intake of alcohol (< 30 mL/day). In men, smoking and body mass index accounted for 28 % and 26 % of the variation in high-sensitivity C-reactive protein, respectively, while body mass index accounted for 60 % of the variation of high-sensitivity C-reactive protein in women. Conclusions: Smoking and body mass index in men, and body mass index in women, were major correlates of serum high-sensitivity C-reactive protein in Japanese people.
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U2 - 10.1515/cclm-2011-0839
DO - 10.1515/cclm-2011-0839
M3 - Article
C2 - 22868815
AN - SCOPUS:84867789061
SN - 1434-6621
VL - 50
SP - 1469
EP - 1476
JO - Clinical Chemistry and Laboratory Medicine
JF - Clinical Chemistry and Laboratory Medicine
IS - 8
ER -
