TY - JOUR
T1 - Bcl-2 rescues T lymphopoiesis, but not B or NK cell development, in common γ chain-deficient mice
AU - Kondo, Motonari
AU - Akashi, Koichi
AU - Domen, Jos
AU - Sugamura, Kazuo
AU - Weissman, Irving L.
N1 - Funding Information:
Correspondence should be addressed to M. K. (e-mail: motonari. kondo@stanford.edu). We thank Dr. S. Cory for Eμ-bcl-2 transgenic mice and Dr. L. A. Herzenberg for mouse anti-IgM antibodies. We are grateful to L. Jerabek for laboratory management, V. Braunstein for antibody preparation, T. Knaak for instructions on operating the flow cytometers, L. Hidalgo and B. Lavarro for animal care, Dr. M. Amano for valuable advice for blood cell counting, and Dr. A. Schlageter for critically reviewing the manuscript. M. K. and K. A. were supported by a research fellow program of the Japanese Society for the Promotion of Science. This work was supported mainly by National Cancer Institute grant CA42551.
PY - 1997/7
Y1 - 1997/7
N2 - The common cytokine receptor γ chain (γ{c) is an indispensable subunit for the formation of lymphoid-related cytokine receptors, including IL-7 and IL-15 receptors, that mediate nonredundant or critical signals for the differentiation of T and B cells and natural killer (NK) cells, respectively. We introduced the bcl-2 transgene driven by Eμ or H-2K promoters into γ(c)-deficient mice that lack all three lymphoid subclasses. The forced expression of Bcl-2 restored all stages of T lymphopoiesis, but not B or NK cell development, indicating that a primary function of γ(c)- mediated signals in the T lineage might be to maintain cell survival. Therefore, the development of T, B, and NK cells may be influenced by distinct intracytoplasmic signaling cascades that are activated by coupling of γ(c)-related receptors.
AB - The common cytokine receptor γ chain (γ{c) is an indispensable subunit for the formation of lymphoid-related cytokine receptors, including IL-7 and IL-15 receptors, that mediate nonredundant or critical signals for the differentiation of T and B cells and natural killer (NK) cells, respectively. We introduced the bcl-2 transgene driven by Eμ or H-2K promoters into γ(c)-deficient mice that lack all three lymphoid subclasses. The forced expression of Bcl-2 restored all stages of T lymphopoiesis, but not B or NK cell development, indicating that a primary function of γ(c)- mediated signals in the T lineage might be to maintain cell survival. Therefore, the development of T, B, and NK cells may be influenced by distinct intracytoplasmic signaling cascades that are activated by coupling of γ(c)-related receptors.
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U2 - 10.1016/S1074-7613(00)80518-X
DO - 10.1016/S1074-7613(00)80518-X
M3 - Article
C2 - 9252128
AN - SCOPUS:0030787787
SN - 1074-7613
VL - 7
SP - 155
EP - 162
JO - Immunity
JF - Immunity
IS - 1
ER -
