Batf is important for IL-4 expression in T follicular helper cells

Anupama Sahoo, Andrei Alekseev, Kentaro Tanaka, Lidiya Obertas, Beatrisa Lerman, Cara Haymaker, Karen Clise-Dwyer, John S. McMurray, Roza Nurieva

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79 Citations (Scopus)


Apart from T helper (Th)-2 cells, T follicular helper (Tfh) cells are a major class of IL-4-producing T cells, required for regulation of type 2 humoral immunity; however, transcriptional control of IL-4 production in Tfh cells remains mainly unknown. Here, we show that the basic leucine zipper transcription factor ATF-like, Batf is important for IL-4 expression in Tfh cells rather than in canonical Th2 cells. Functionally, Batf in cooperation with interferon regulatory factor (IRF) 4 along with Stat3 and Stat6 trigger IL-4 production in Tfh cells by directly binding to and activation of the CNS2 region in the IL-4 locus. In addition, Batf-to-c-Maf signalling is an important determinant of IL-4 expression in Tfh cells. Batf deficiency impairs the generation of IL-4-producing Tfh cells that results in protection against allergic asthma. Our results thus indicate a positive role of Batf in promoting the generation of pro-allergic IL-4-producing Tfh cells.

Original languageEnglish
Article number7997
JournalNature communications
Publication statusPublished - Aug 17 2015
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General
  • General Physics and Astronomy
  • General Chemistry
  • General Biochemistry,Genetics and Molecular Biology


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