Basic properties of apatite cement containing carbonate apatite and its resorption by cultured osteoclasts

Y. Miyamoto, T. Toh, T. Yuasa, M. Takechi, Y. Momota, M. Nagayama, K. Ishikawa, K. Suzuki

Research output: Contribution to journalConference articlepeer-review

3 Citations (Scopus)


Apatite cement (AC) has received much attention as a new reconstructive material for bony defects because AC transforms to hydroxyapatite (HAP) and shows excellent tissue response and osteoconductivity. In addition, AC has been reported to be partly replaced with bone, although the process takes a long time. The aim of this study, therefore, is to fabricate bone-replacing apatite cement by converting AC to be easily resorbed by osteoclasts. For this purpose, NaHCO3 was added into the AC component. The amount of CO3 incorporated into the set AC increased with the amount of added NaHCO3. B-type carbonate apatite (CO3-AP) was formed in the set AC added NaHCO3. The dissolution rate of the set AC in weak acid, pH 5.5, increased with NaHCO3. The number of resorption pits and the resorbed area by cultured osteoclasts increased with added CO3 content. The resorbed area on 4% CO3-added-AC was twice as much as that of carbonate-free-AC. The results suggested that CO3-AP-formed AC would be easily resorbed by osteoclasts.

Original languageEnglish
Pages (from-to)829-832
Number of pages4
JournalKey Engineering Materials
Publication statusPublished - 2001
Externally publishedYes
Event13th international Symposium on Ceramics in Medicine (BIOCERAMICS) - Bologna, Italy
Duration: Nov 22 2000Nov 26 2000

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering


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