Baroreflex failure and beat-to-beat blood pressure variation

Takuya Kishi

    Research output: Contribution to journalReview articlepeer-review

    29 Citations (Scopus)


    Hypertension has strong adverse effects on cardiovascular diseases, and increased blood pressure (BP) variability (BPV) is closely associated with the development of hypertensive organ injuries and the occurrence of cardiovascular diseases. Similar to other forms of BPV, short-term beat-to-beat BPV has also been established as a risk factor for cardiovascular diseases. Baroreflex failure is the major mechanism involved in the pathophysiology of short-term beat-to-beat BPV. Previous clinical and animal studies have demonstrated that baroreflex failure disrupted beat-to-beat BPV and hypertensive organ damage. Moreover, short-term beat-to-beat BPV was an independent determinant of vascular elasticity. Although, the clinical measurement tools and therapeutics for beat-to-beat BPV are not sufficient, we should consider that large beat-to-beat BPV is an important risk factor for cardiovascular diseases in patients with hypertension.

    Original languageEnglish
    Pages (from-to)547-552
    Number of pages6
    JournalHypertension Research
    Issue number8
    Publication statusPublished - Aug 1 2018

    All Science Journal Classification (ASJC) codes

    • Internal Medicine
    • Physiology
    • Cardiology and Cardiovascular Medicine


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