Accurately predicting the development of Autism Spectrum Disorder (ASD) in early childhood would have major implications for maximizing treatment efficacy. Magnetoencephalography (MEG) and near infrared spectroscopy (NIRS) are non-invasive, instant and low-constraint measurement techniques which allow us to study brain functioning even in young children without any sedation. Using NIRS, we investigated brain hemodynamic responses in frontal areas during letter-cued verbal fluency tests in 21 normal controls and 24 patients with ASD. Results suggest that these parameters must be sensitive physiological markers of ASD. In addition, we have done a pilot study in one patient with ASD using MEG The results suggest that the brain responses elicited by visual biological motion stimuli could be sensitive physiological markers of ASD. Finally, we shortly introduce our new project (Bambi plan) with a NIRS/MEG integrated device. This ongoing project pursues engineering development for an integrated MEG/NIRS device and aims to evaluate the performance of this novel device in the early diagnosis of ASD.
|Number of pages
|Journal of Brain Science
|Published - 2009
All Science Journal Classification (ASJC) codes
- General Neuroscience