TY - JOUR
T1 - Bacteriological and clinical studies on meropenem
AU - Sawae, Yoshiro
AU - Shimono, Nobuyuki
AU - Misumi, Hiroyasu
AU - Eguchi, Katsuhiko
AU - Takita, Atsushi
AU - Higuchi, Kazuyuki
AU - Okada, Kaoru
AU - Takii, Masahide
AU - Fukuma, Michio
AU - Ninomiya, Kiyoshi
AU - Oshima, Tsukasa
AU - Sumita, Ikuo
AU - Inoue, Takatoshi
AU - Kumagai, Yukio
AU - Ishimaru, Toshiyuki
PY - 1992/4
Y1 - 1992/4
N2 - We performed bacteriological and clinical studies on meropenem (MEPM), a new parenteral carbapenem antibiotic, with the following results. 1. Antibacterial activity The MICs of MEPM against various clinical isolates were detemined with an inoculum size of 106 cell/ml. The MIC90 was 6.25 µg/ml for Staphylococcus aureus, 25 for Enterococcus faecalis, ≦0.05 for Escherichia coli, 0.1 for Klebsiella pneumoniae, Proteus mirabilis and Proteus vulgaris, 1.56 for Enterobacter cloacae, 3.13 for Enterobacter aerogenes, 0.39 for Serratia marcescens, 0.78 for Citrobacter freundii and, 50 for Pseudomonas aeruginosa. Its activity against gram-positive cocci was less than that of imipenem (IPM), but against gram-negative rods other than P. aeruginosa its activity was more potent than IPM, ceftazidime (CAZ) cefoperazone (CPZ), and piperacillin (PIPC). Its activity against P. aeruginosa was the same as that of IPM and CAZ, but more active than CPZ and PIPC.
AB - We performed bacteriological and clinical studies on meropenem (MEPM), a new parenteral carbapenem antibiotic, with the following results. 1. Antibacterial activity The MICs of MEPM against various clinical isolates were detemined with an inoculum size of 106 cell/ml. The MIC90 was 6.25 µg/ml for Staphylococcus aureus, 25 for Enterococcus faecalis, ≦0.05 for Escherichia coli, 0.1 for Klebsiella pneumoniae, Proteus mirabilis and Proteus vulgaris, 1.56 for Enterobacter cloacae, 3.13 for Enterobacter aerogenes, 0.39 for Serratia marcescens, 0.78 for Citrobacter freundii and, 50 for Pseudomonas aeruginosa. Its activity against gram-positive cocci was less than that of imipenem (IPM), but against gram-negative rods other than P. aeruginosa its activity was more potent than IPM, ceftazidime (CAZ) cefoperazone (CPZ), and piperacillin (PIPC). Its activity against P. aeruginosa was the same as that of IPM and CAZ, but more active than CPZ and PIPC.
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U2 - 10.11250/chemotherapy1953.40.Supplement1_401
DO - 10.11250/chemotherapy1953.40.Supplement1_401
M3 - Article
AN - SCOPUS:0026750765
SN - 0009-3165
VL - 40
SP - 401
EP - 411
JO - Chemotherapy
JF - Chemotherapy
ER -
