Bactericidal activity of nukacin ISK-1: An alternative mode of action

Urmi Roy, Mohammad Riazul Islam, Jun Ichi Nagao, Hiroshi Iida, Abdullah Al Mahin, Mengqi Li, Takeshi Zendo, Jiro Nakayama, Kenji Sonomoto

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


We previously reported bacteriostatic action of nukacin ISK-1 against Bacillus subtilis JCM 1465T. Here, we found its bactericidal activity against Micrococcus luteus DSM 1790 and Staphylococcus simulans 22, showing decrease in cell viability, cell lysis, and dissipation of the membrane potential. Moreover, leakage of small molecules such as K+, suggested the formation of small-sized or specific K+-conducting-pores by nukacin ISK-1.

Original languageEnglish
Pages (from-to)1270-1273
Number of pages4
JournalBioscience, Biotechnology and Biochemistry
Issue number7
Publication statusPublished - 2014

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry


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