TY - JOUR
T1 - Bactericidal activity of nukacin ISK-1
T2 - An alternative mode of action
AU - Roy, Urmi
AU - Islam, Mohammad Riazul
AU - Nagao, Jun Ichi
AU - Iida, Hiroshi
AU - Mahin, Abdullah Al
AU - Li, Mengqi
AU - Zendo, Takeshi
AU - Nakayama, Jiro
AU - Sonomoto, Kenji
N1 - Funding Information:
This work was partially supported by JSPS KAKENHI [grant number 23380050], and grants from the Japan Science Society, the Novartis Foundation (Japan) for the Promotion of Science, the Novozymes Japan Research Fund, and the Nagase Science and Technology Foundation.
Publisher Copyright:
© 2014 Japan Society for Bioscience, Biotechnology, and Agrochemistry.
PY - 2014
Y1 - 2014
N2 - We previously reported bacteriostatic action of nukacin ISK-1 against Bacillus subtilis JCM 1465T. Here, we found its bactericidal activity against Micrococcus luteus DSM 1790 and Staphylococcus simulans 22, showing decrease in cell viability, cell lysis, and dissipation of the membrane potential. Moreover, leakage of small molecules such as K+, suggested the formation of small-sized or specific K+-conducting-pores by nukacin ISK-1.
AB - We previously reported bacteriostatic action of nukacin ISK-1 against Bacillus subtilis JCM 1465T. Here, we found its bactericidal activity against Micrococcus luteus DSM 1790 and Staphylococcus simulans 22, showing decrease in cell viability, cell lysis, and dissipation of the membrane potential. Moreover, leakage of small molecules such as K+, suggested the formation of small-sized or specific K+-conducting-pores by nukacin ISK-1.
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U2 - 10.1080/09168451.2014.918485
DO - 10.1080/09168451.2014.918485
M3 - Article
C2 - 25229869
AN - SCOPUS:84930714307
SN - 0916-8451
VL - 78
SP - 1270
EP - 1273
JO - Bioscience, Biotechnology and Biochemistry
JF - Bioscience, Biotechnology and Biochemistry
IS - 7
ER -