B cell signaling and fate decision

Tomohiro Kurosaki, Hisaaki Shinohara, Yoshihiro Baba

Research output: Contribution to journalReview articlepeer-review

268 Citations (Scopus)


Antigen receptors on the surface of B lymphocytes trigger adaptive immune responses after encountering their cognate antigens but also control a series of antigen-independent checkpoints during B cell development. These physiological processes are regulated by the expression and function of cell surface receptors, intracellular signaling molecules, and transcription factors. The function of these proteins can be altered by a dynamic array of post-translational modifications, using two interconnected mechanisms. These modifications can directly induce an altered conformational state in the protein target of the modification itself. In addition, they can create new binding sites for other protein partners, thereby contributing to where and when such multiple protein assemblies are activated within cells. As a new type of post-transcriptional regulator, microRNAs have emerged to luence the development and function of B cells by affecting the expression of target mRNAs.

Original languageEnglish
Pages (from-to)21-55
Number of pages35
JournalAnnual Review of Immunology
Publication statusPublished - Apr 23 2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology


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