(-)-Axinyssene: A novel cytotoxic diterpene from a Japanese marine sponge Axinyssa sp

Kota Kodama; Ryuichi Higuchi; Tomofumi Miyamoto; Rob W.M. Van Soest

doi:10.1021/ol027202f

(-)-Axinyssene: A novel cytotoxic diterpene from a Japanese marine sponge Axinyssa sp

Kota Kodama, Ryuichi Higuchi, Tomofumi Miyamoto, Rob W.M. Van Soest

Pharmaceutical Health Care and Sciences

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

(Matrix presented) A novel diterpene, (-)-axinyssene, was isolated from the Japanese marine sponge Axinyssa sp. The structure of (-)-axinyssene was determined on the basis of spectroscopic and synthetic evidence to be 1-methyl-4-[(4E)-5′9′-dimethyl-1′-methylene-4′, 8′-decadienyl]-(4S)-cyclohexene. (-)- and (+)-axinyssene showed mild cytotoxicity against acute promyelocytic leukemia, HL-60 cells.

Original language	English
Pages (from-to)	169-171
Number of pages	3
Journal	Organic letters
Volume	5
Issue number	2
DOIs	https://doi.org/10.1021/ol027202f
Publication status	Published - Jan 23 2003

All Science Journal Classification (ASJC) codes

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol027202f

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abstract = "(Matrix presented) A novel diterpene, (-)-axinyssene, was isolated from the Japanese marine sponge Axinyssa sp. The structure of (-)-axinyssene was determined on the basis of spectroscopic and synthetic evidence to be 1-methyl-4-[(4E)-5′9′-dimethyl-1′-methylene-4′, 8′-decadienyl]-(4S)-cyclohexene. (-)- and (+)-axinyssene showed mild cytotoxicity against acute promyelocytic leukemia, HL-60 cells.",

author = "Kota Kodama and Ryuichi Higuchi and Tomofumi Miyamoto and {Van Soest}, {Rob W.M.}",

year = "2003",

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T1 - (-)-Axinyssene

T2 - A novel cytotoxic diterpene from a Japanese marine sponge Axinyssa sp

AU - Kodama, Kota

AU - Higuchi, Ryuichi

AU - Miyamoto, Tomofumi

AU - Van Soest, Rob W.M.

PY - 2003/1/23

Y1 - 2003/1/23

N2 - (Matrix presented) A novel diterpene, (-)-axinyssene, was isolated from the Japanese marine sponge Axinyssa sp. The structure of (-)-axinyssene was determined on the basis of spectroscopic and synthetic evidence to be 1-methyl-4-[(4E)-5′9′-dimethyl-1′-methylene-4′, 8′-decadienyl]-(4S)-cyclohexene. (-)- and (+)-axinyssene showed mild cytotoxicity against acute promyelocytic leukemia, HL-60 cells.

AB - (Matrix presented) A novel diterpene, (-)-axinyssene, was isolated from the Japanese marine sponge Axinyssa sp. The structure of (-)-axinyssene was determined on the basis of spectroscopic and synthetic evidence to be 1-methyl-4-[(4E)-5′9′-dimethyl-1′-methylene-4′, 8′-decadienyl]-(4S)-cyclohexene. (-)- and (+)-axinyssene showed mild cytotoxicity against acute promyelocytic leukemia, HL-60 cells.

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JO - Organic letters

JF - Organic letters

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(-)-Axinyssene: A novel cytotoxic diterpene from a Japanese marine sponge Axinyssa sp

Abstract

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