TY - JOUR
T1 - Availability of Pancreatic Allograft Biopsies Via a Laparotomy
AU - Kitada, H.
AU - Sugitani, A.
AU - Okabe, Y.
AU - Doi, Atsushi
AU - Nishiki, T.
AU - Miura, Y.
AU - Kurihara, Kei
AU - Tanaka, M.
PY - 2009/12
Y1 - 2009/12
N2 - Objective: The aim of this study was to evaluate the availability of a pancreatic allograft biopsy via a laparotpmy. Patients and Methods: From September 2004 to November 2007, 17 pancreas transplantations were performed: 15 simultaneous pancreas and kidney transplantations (SPK), 1 pancreas transplant alone (PTA), and one pancreas after kidney transplantation (PAK). Thirteen pancreatic allograft biopsies were obtained via an open laparotomy. This study evaluated the complications associated with this procedure, the rate of obtaining an adequate sample, and the relationship between biopsy-proven rejections and laboratory markers. In SPK cases we evaluated the synchronization between pancreas and kidney rejection. The pancreatic samples were diagnosed according to the Drachenberg classification. Results: No complications resulted from the procedure. The rate of obtaining adequate samples was 84.6%. Pancreas rejection correlated with elevation of the laboratory markers in 71.4%. Simultaneous pancreas and kidney rejection occurred in 62.5%, only kidney in 25%, and only pancreas in 12.5%. Conclusion: A pancreas graft biopsy was absolutely imperative to improve the outcome in PTA, and even in SPK cases. A pancreatic allograft biopsy via a laparotomy was a safe, necessary and easy procedure to obtain an accurate diagnosis of rejection among pancreas transplantation patients.
AB - Objective: The aim of this study was to evaluate the availability of a pancreatic allograft biopsy via a laparotpmy. Patients and Methods: From September 2004 to November 2007, 17 pancreas transplantations were performed: 15 simultaneous pancreas and kidney transplantations (SPK), 1 pancreas transplant alone (PTA), and one pancreas after kidney transplantation (PAK). Thirteen pancreatic allograft biopsies were obtained via an open laparotomy. This study evaluated the complications associated with this procedure, the rate of obtaining an adequate sample, and the relationship between biopsy-proven rejections and laboratory markers. In SPK cases we evaluated the synchronization between pancreas and kidney rejection. The pancreatic samples were diagnosed according to the Drachenberg classification. Results: No complications resulted from the procedure. The rate of obtaining adequate samples was 84.6%. Pancreas rejection correlated with elevation of the laboratory markers in 71.4%. Simultaneous pancreas and kidney rejection occurred in 62.5%, only kidney in 25%, and only pancreas in 12.5%. Conclusion: A pancreas graft biopsy was absolutely imperative to improve the outcome in PTA, and even in SPK cases. A pancreatic allograft biopsy via a laparotomy was a safe, necessary and easy procedure to obtain an accurate diagnosis of rejection among pancreas transplantation patients.
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U2 - 10.1016/j.transproceed.2009.09.066
DO - 10.1016/j.transproceed.2009.09.066
M3 - Article
C2 - 20005383
AN - SCOPUS:71249120173
SN - 0041-1345
VL - 41
SP - 4274
EP - 4276
JO - Transplantation Proceedings
JF - Transplantation Proceedings
IS - 10
ER -