Autophagy in the fission yeast Schizosaccharomyces pombe

Hiroyuki Mukaiyama, Mai Nakase, Taro Nakamura, Yoshimi Kakinuma, Kaoru Takegawa

Research output: Contribution to journalReview articlepeer-review

34 Citations (Scopus)


Autophagy is a non-selective degradation process in eukaryotic cells. The genome sequence of the fission yeast Schizosaccharomyces pombe has revealed that many of the genes required for autophagy are common between the fission yeast and budding yeast, suggesting that the basic machinery of autophagy is conserved between these species. Autophagy in fission yeast is specifically induced by nitrogen starvation based on monitoring a GFP-Atg8p marker. Upon nitrogen starvation, fission yeast cells exit the vegetative cell cycle and initiate sexual differentiation to produce spores. Most of the nitrogen used for de novo protein synthesis during sporulation derives from the autophagic protein degradation system. This review focuses on the recent advances in the role of autophagy in fission yeast.

Original languageEnglish
Pages (from-to)1327-1334
Number of pages8
JournalFEBS Letters
Issue number7
Publication statusPublished - Apr 2010

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology


Dive into the research topics of 'Autophagy in the fission yeast Schizosaccharomyces pombe'. Together they form a unique fingerprint.

Cite this