Autoimmune pancreatitis diagnosed after pancreatoduodenectomy and successfully treated with low-dose steroid

Masato Watanabe, Koji Yamaguchi, Kiichiro Kobayashi, Hiroyuki Konomi, Masafumi Nakamura, Kazuhiro Mizumoto, Masazumi Tsuneyoshi, Masao Tanaka

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


A 69-year-old woman presented with obstructive jaundice and a 30-mm hypoechoic mass in the pancreatic head on ultrasonography. Magnetic resonance imaging (MRI) revealed enlargement of the pancreatic head with dilatation of the upstream main pancreatic duct and no dilatation of the proximal biliary tree. Endoscopic retrograde pancreatography showed a localized irregular narrowing of the main pancreatic duct in the head of the pancreas. Pylorus-preserving pancreatoduodenectomy (PPPD) was performed under the diagnosis of pancreatic head cancer. Histopathological examination showed fibrosis with lymphoplasmacytic infiltration, suggesting the diagnosis of autoimmune pancreatitis (AIP). Serum IgG concentration was within normal limits immediately after the operation but was elevated 4 months later, when MRI showed enlargement of the remnant pancreas, with a peripheral rim of low intensity. Oral administration of prednisolone was initiated, at a dose of 5 mg/day. The serum IgG concentration declined and MRI showed improvement of the pancreatic enlargement and the disappearance of the peripheral rim. AIP has not relapsed for 1 year so far, with the patient being kept on 5 mg/ day prednisolone. This communication reports a patient with AIP showing an interesting clinical course.

Original languageEnglish
Pages (from-to)397-400
Number of pages4
JournalJournal of Hepato-Biliary-Pancreatic Surgery
Issue number4
Publication statusPublished - Jul 2007

All Science Journal Classification (ASJC) codes

  • Surgery
  • Hepatology


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